Bleeding time
Encyclopedia
Bleeding time is a medical test
done on someone to assess their platelet
function
The term "template bleeding time" is used when the test is performed to standardized parameters. This makes it easier to compare data collected at different facilities.
s. The cut is of a standardised width and depth, and is done quickly by an automatic device.
A blood pressure cuff is used above the wound, to maintain venous pressure at a special value. The time it takes for bleeding to stop (as thus the time it takes for a platelet plug to form) is measured. Cessation of bleeding can be determined by blotting away the blood every several seconds until the site looks 'glassy'.
A standard-sized incision is made around 10 mm long and 1 mm deep. The time from when the incision is made until all bleeding has stopped is measured and is called the bleeding time. Every 30 seconds, filter paper or a paper towel is used to draw off the blood.
The test is finished when bleeding has stopped completely.
A normal value is less than 9 and a half minutes.
A prolonged bleeding time may be a result from decreased number of thrombocytes or impaired blood vessels. However, it should also be noted that the depth of the puncture or incision may be the source of error.
Normal values
fall between 2 – 9 minutes depending on the method used.
or fingertip, after having been swabbed with alcohol. The prick is about 3–4 mm deep. The patient then wipes the blood every 30 seconds with a filter paper. The test ceases when bleeding ceases. The usual time is about 1–3 minutes.
--not by other coagulation factors
such as haemophilia
. Diseases that cause prolonged bleeding time include thrombocytopenia
, disseminated intravascular coagulation
(DIC), Bernard-Soulier disease, and Glanzmann's thrombasthenia
.
Aspirin
and other cyclooxygenase
inhibitors can prolong bleeding time significantly. While warfarin
and heparin
have their major effects on coagulation factors, an increased bleeding time is sometimes seen with use of these medications as well.
People with von Willebrand disease
usually experience increased bleeding time, as von Willebrand factor
is a platelet agglutination protein, but this is not considered an effective diagnostic test for this condition.
It is also prolonged in hypofibrinogenemia.
Medical test
A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example:* to diagnose diseases, and preferably sub-classify it regarding, for example, severity and treatability...
done on someone to assess their platelet
Platelet
Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...
function
The term "template bleeding time" is used when the test is performed to standardized parameters. This makes it easier to compare data collected at different facilities.
Process
It involves cutting the underside of the subject's forearm, in an area where there is no hair or visible veinVein
In the circulatory system, veins are blood vessels that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated blood to the heart...
s. The cut is of a standardised width and depth, and is done quickly by an automatic device.
A blood pressure cuff is used above the wound, to maintain venous pressure at a special value. The time it takes for bleeding to stop (as thus the time it takes for a platelet plug to form) is measured. Cessation of bleeding can be determined by blotting away the blood every several seconds until the site looks 'glassy'.
Ivy method
The Ivy method is the traditional format for this test. While both the Ivy and the Duke method require the use of a sphygmomanometer, or blood pressure cuff, the Ivy method is more invasive than the Duke method, utilizing an incision on the ventral side of the forearm, whereas the Duke method involves puncture with a lancet or special needle. In the Ivy method, the blood pressure cuff is placed on the upper arm and inflated to 40 mmHg. A lancet or scalpel blade is used to make a shallow incision that is 1 millimeter deep on the underside of the forearm.A standard-sized incision is made around 10 mm long and 1 mm deep. The time from when the incision is made until all bleeding has stopped is measured and is called the bleeding time. Every 30 seconds, filter paper or a paper towel is used to draw off the blood.
The test is finished when bleeding has stopped completely.
A normal value is less than 9 and a half minutes.
A prolonged bleeding time may be a result from decreased number of thrombocytes or impaired blood vessels. However, it should also be noted that the depth of the puncture or incision may be the source of error.
Normal values
Reference ranges for common blood tests
Reference ranges for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples....
fall between 2 – 9 minutes depending on the method used.
Duke Method
With the Duke method, the patient is pricked with a special needle or lancet, preferably on the earlobeEarlobe
The human earlobe is composed of tough areolar and adipose connective tissues, lacking the firmness and elasticity of the rest of the pinna. Since the earlobe does not contain cartilage it has a large blood supply and may help to warm the ears and maintain balance. However earlobes are not...
or fingertip, after having been swabbed with alcohol. The prick is about 3–4 mm deep. The patient then wipes the blood every 30 seconds with a filter paper. The test ceases when bleeding ceases. The usual time is about 1–3 minutes.
Interpretation
Bleeding time is affected by platelet function, certain vascular disorders and von Willebrand DiseaseVon Willebrand disease
von Willebrand disease is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor , a multimeric protein that is required for...
--not by other coagulation factors
Coagulation
Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
such as haemophilia
Haemophilia
Haemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. Haemophilia A is the most common form of the disorder, present in about 1 in 5,000–10,000 male births...
. Diseases that cause prolonged bleeding time include thrombocytopenia
Thrombocytopenia
Thrombocytopenia is a relative decrease of platelets in blood.A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. These limits are determined by the 2.5th lower and upper percentile, so values outside this range do not necessarily indicate disease...
, disseminated intravascular coagulation
Disseminated intravascular coagulation
Disseminated intravascular coagulation , also known as disseminated intravascular coagulopathy or consumptive coagulopathy, is a pathological activation of coagulation mechanisms that happens in response to a variety of diseases. DIC leads to the formation of small blood clots inside the blood...
(DIC), Bernard-Soulier disease, and Glanzmann's thrombasthenia
Glanzmann's thrombasthenia
Glanzmann's thrombasthenia is an abnormality of platelets. It is an extremely rare coagulopathy , in which the platelets lack glycoprotein IIb/IIIa...
.
Aspirin
Aspirin
Aspirin , also known as acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. It was discovered by Arthur Eichengrun, a chemist with the German company Bayer...
and other cyclooxygenase
Cyclooxygenase
Cyclooxygenase is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain...
inhibitors can prolong bleeding time significantly. While warfarin
Warfarin
Warfarin is an anticoagulant. It is most likely to be the drug popularly referred to as a "blood thinner," yet this is a misnomer, since it does not affect the thickness or viscosity of blood...
and heparin
Heparin
Heparin , also known as unfractionated heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule...
have their major effects on coagulation factors, an increased bleeding time is sometimes seen with use of these medications as well.
People with von Willebrand disease
Von Willebrand disease
von Willebrand disease is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor , a multimeric protein that is required for...
usually experience increased bleeding time, as von Willebrand factor
Von Willebrand factor
von Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...
is a platelet agglutination protein, but this is not considered an effective diagnostic test for this condition.
It is also prolonged in hypofibrinogenemia.