Augustus d'Este
Encyclopedia
Sir Augustus Frederick d'Este KCB
KCH
(1794–1848) was the son of Prince Augustus Frederick, Duke of Sussex
and Lady Augusta Murray
and the grandson of George III
. His parents' otherwise legitimate marriages were in contravention of the Royal Marriages Act 1772
, which meant that Augustus d'Este was illegitimate for purposes of British law.
An active member of the Aborigines Protection Society particularly interested in native Americans he gave considerable assistance to Peter Jones
, the Mississauga
missionary and leader to argue for title to their lands in Upper Canada
.
Augustus d’Este is the earliest recorded person for whom a definite diagnosis of multiple sclerosis
can be made. The course of his MS, which was not diagnosed during his lifetime, is known from the diaries he kept. D'Este left a detailed diary describing his 22 years living with the disease. He began his diary in 1822 and it had its last entry in 1846; only to remain unknown until 1948.
His symptoms began at age 28 with a sudden transient visual loss after the funeral of a friend. During the course of his disease he developed weakness of the legs, clumsiness of the hands, numbness, dizziness, bladder disturbances, and erectile dysfunction
. By 1843 he was experiencing persistent symptoms including tremor and nocturnal spasms, and in 1844 he began to use a wheelchair
. In his last years he was confined to his bed. Despite his illness, he kept an optimistic view of life.
Order of the Bath
The Most Honourable Order of the Bath is a British order of chivalry founded by George I on 18 May 1725. The name derives from the elaborate mediæval ceremony for creating a knight, which involved bathing as one of its elements. The knights so created were known as Knights of the Bath...
KCH
Royal Guelphic Order
The Royal Guelphic Order, sometimes also referred to as the Hanoverian Guelphic Order, is a Hanoverian order of chivalry instituted on 28 April 1815 by the Prince Regent . It has not been conferred by the British Crown since the death of King William IV in 1837, when the personal union of the...
(1794–1848) was the son of Prince Augustus Frederick, Duke of Sussex
Prince Augustus Frederick, Duke of Sussex
The Prince Augustus Frederick, Duke of Sussex , was the sixth son of George III of the United Kingdom and his consort, Charlotte of Mecklenburg-Strelitz. He was the only surviving son of George III who did not pursue an army or naval career.- Early life :His Royal Highness The Prince Augustus...
and Lady Augusta Murray
Lady Augusta Murray
The Lady Augusta Murray was the first wife of Prince Augustus Frederick, Duke of Sussex, the sixth son of George III. As their marriage was in contravention of the Royal Marriages Act 1772, it was considered legally void, and she could not be styled as the Duchess of Sussex.-Early life:Lady...
and the grandson of George III
George III of the United Kingdom
George III was King of Great Britain and King of Ireland from 25 October 1760 until the union of these two countries on 1 January 1801, after which he was King of the United Kingdom of Great Britain and Ireland until his death...
. His parents' otherwise legitimate marriages were in contravention of the Royal Marriages Act 1772
Royal Marriages Act 1772
The Royal Marriages Act 1772 is an Act of the Parliament of Great Britain which prescribes the conditions under which members of the British Royal Family may contract a valid marriage, in order to guard against marriages that could diminish the status of the Royal House...
, which meant that Augustus d'Este was illegitimate for purposes of British law.
An active member of the Aborigines Protection Society particularly interested in native Americans he gave considerable assistance to Peter Jones
Peter Jones
Peter Jones or Pete Jones may refer to:*Peter Jones , English actor*Peter Jones , Australian rules footballer for Carlton...
, the Mississauga
Mississaugas
The Mississaugas are a subtribe of the Anishinaabe-speaking First Nations people located in southern Ontario, Canada. They are closely related to the Ojibwa...
missionary and leader to argue for title to their lands in Upper Canada
Upper Canada
The Province of Upper Canada was a political division in British Canada established in 1791 by the British Empire to govern the central third of the lands in British North America and to accommodate Loyalist refugees from the United States of America after the American Revolution...
.
Augustus d’Este is the earliest recorded person for whom a definite diagnosis of multiple sclerosis
Multiple sclerosis
Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...
can be made. The course of his MS, which was not diagnosed during his lifetime, is known from the diaries he kept. D'Este left a detailed diary describing his 22 years living with the disease. He began his diary in 1822 and it had its last entry in 1846; only to remain unknown until 1948.
His symptoms began at age 28 with a sudden transient visual loss after the funeral of a friend. During the course of his disease he developed weakness of the legs, clumsiness of the hands, numbness, dizziness, bladder disturbances, and erectile dysfunction
Erectile dysfunction
Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual performance....
. By 1843 he was experiencing persistent symptoms including tremor and nocturnal spasms, and in 1844 he began to use a wheelchair
Wheelchair
A wheelchair is a chair with wheels, designed to be a replacement for walking. The device comes in variations where it is propelled by motors or by the seated occupant turning the rear wheels by hand. Often there are handles behind the seat for someone else to do the pushing...
. In his last years he was confined to his bed. Despite his illness, he kept an optimistic view of life.