Asen Hadjiolov
Encyclopedia
Bulgaria
Bulgaria , officially the Republic of Bulgaria , is a parliamentary democracy within a unitary constitutional republic in Southeast Europe. The country borders Romania to the north, Serbia and Macedonia to the west, Greece and Turkey to the south, as well as the Black Sea to the east...
, and was a member of the Bulgarian Academy of Sciences
Bulgarian Academy of Sciences
The Bulgarian Academy of Sciences is the National Academy of Bulgaria, established in 1869. The Academy is autonomous and has a Society of Academicians, Correspondent Members and Foreign Members...
.
Vita in brief
Dr. Hadjiolov's scholarly research on the nucleolus
Nucleolus
The nucleolus is a non-membrane bound structure composed of proteins and nucleic acids found within the nucleus. Ribosomal RNA is transcribed and assembled within the nucleolus...
and ribosome
Ribosome
A ribosome is a component of cells that assembles the twenty specific amino acid molecules to form the particular protein molecule determined by the nucleotide sequence of an RNA molecule....
biogenesis and his leadership in the scientific community touched many lives. As a young researcher he followed the path of his father: Professor Asen I. Hadjiolov was a well-known Bulgarian
Bulgarians
The Bulgarians are a South Slavic nation and ethnic group native to Bulgaria and neighbouring regions. Emigration has resulted in immigrant communities in a number of other countries.-History and ethnogenesis:...
histologist and cytologist. Dr. Hadjiolov began experimental work in the Department of Biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
of the Medical Faculty of Sofia
Sofia
Sofia is the capital and largest city of Bulgaria and the 12th largest city in the European Union with a population of 1.27 million people. It is located in western Bulgaria, at the foot of Mount Vitosha and approximately at the centre of the Balkan Peninsula.Prehistoric settlements were excavated...
and was awarded the PhD in 1958 for his studies on the role of nucleic acids in cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
. In 1963 Dr. Hadjiolov became chair of the Department of Molecular Genetics
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....
in the Central Laboratory of Biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
, which was transformed into the Institute of Molecular Biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
of the Bulgarian Academy of Sciences
Bulgarian Academy of Sciences
The Bulgarian Academy of Sciences is the National Academy of Bulgaria, established in 1869. The Academy is autonomous and has a Society of Academicians, Correspondent Members and Foreign Members...
in 1969. During his early years, Dr. Hadjiolov had the chance to work with such eminent scientists as F.B. Straub (Budapest
Budapest
Budapest is the capital of Hungary. As the largest city of Hungary, it is the country's principal political, cultural, commercial, industrial, and transportation centre. In 2011, Budapest had 1,733,685 inhabitants, down from its 1989 peak of 2,113,645 due to suburbanization. The Budapest Commuter...
), R Grabar (Paris), the Nobel Prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...
winner Fritz Lipmann (Cold Spring Harbor, New York
Cold Spring Harbor, New York
Cold Spring Harbor is a hamlet in Suffolk County, New York on the North Shore of Long Island. As of the United States 2000 Census, the CDP population was 4,975.Cold Spring Harbor is in the Town of Huntington.-History:...
) and later with R. Cox (London) and D. Sabatini (New York). Early on, he became fascinated by the structure and biosynthesis of ribosomal RNA
Ribosomal RNA
Ribosomal ribonucleic acid is the RNA component of the ribosome, the enzyme that is the site of protein synthesis in all living cells. Ribosomal RNA provides a mechanism for decoding mRNA into amino acids and interacts with tRNAs during translation by providing peptidyl transferase activity...
(rRNA) and the biogenesis of eukaryotic ribosomes.
Mechanisms of regulation of rRNA synthesis
Gênes
Gênes is the name of a département of the First French Empire in present Italy, named after the city of Genoa. It was formed in 1805, when Napoleon Bonaparte occupied the Republic of Genoa. Its capital was Genoa, and it was divided in the arrondissements of Genoa, Bobbio, Novi Ligure, Tortona and...
. During his active research years Dr. Hadjiolov published more than hundred of articles focused on the ribosome
Ribosome
A ribosome is a component of cells that assembles the twenty specific amino acid molecules to form the particular protein molecule determined by the nucleotide sequence of an RNA molecule....
(see PubMed
PubMed
PubMed is a free database accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine at the National Institutes of Health maintains the database as part of the Entrez information retrieval system...
for a complete list). Dr. Hadjiolov's list of publications totals 106 listed in PubMed. Dr. Hadjiolov's contribution to the world's science can also be measured by contribution of the scientists he recruited and supported throughout his career. All together the heritage of his group exceeds 1,000 articles annotated by PubMed
PubMed
PubMed is a free database accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine at the National Institutes of Health maintains the database as part of the Entrez information retrieval system...
, which matches today's highest quantitative achievements in science. For example, the most cited author since 1994 by the Institute for Scientific Information
Institute for Scientific Information
The Institute for Scientific Information was founded by Eugene Garfield in 1960. It was acquired by Thomson Scientific & Healthcare in 1992, became known as Thomson ISI and now is part of the Healthcare & Science business of the multi-billion dollar Thomson Reuters Corporation.ISI offered...
's Citation Report, Dr. John C. Reed (Burnham Institute for Medical Research
Burnham Institute for Medical Research
The Sanford-Burnham Medical Research Institute, previously Burnham Institute for Medical Research, is a non-profit medical research institute with locations in La Jolla, California, Orlando, Florida, and Santa Barbara, California...
) and his group have reached similar number of articles (PubMed
PubMed
PubMed is a free database accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine at the National Institutes of Health maintains the database as part of the Entrez information retrieval system...
:728 as of April 4, 2007).
Science Heritage
PubMed
PubMed is a free database accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine at the National Institutes of Health maintains the database as part of the Entrez information retrieval system...
count > 860 articles):
- ♦ Krasimira V. Hadjiolova, PhD (12) not active in research
- ♦ Nikolai Nikolaev, PhD (111) (1943 - 2004)
- ♦ Kalin P. Dudov, PhD, (15) Inst. of Genetic Engineering, BulgariaBulgariaBulgaria , officially the Republic of Bulgaria , is a parliamentary democracy within a unitary constitutional republic in Southeast Europe. The country borders Romania to the north, Serbia and Macedonia to the west, Greece and Turkey to the south, as well as the Black Sea to the east...
- ♦ Pencho Venkov, PhD (64) Sofia UniversitySofia UniversityThe St. Clement of Ohrid University of Sofia or Sofia University is the oldest higher education institution in Bulgaria, founded on 1 October 1888...
- ♦ Mariana D. Dabeva, PhD, (57) Albert Einstein College of MedicineAlbert Einstein College of MedicineAlbert Einstein College of Medicine is a graduate school of Yeshiva University. It is a not-for-profit, private, nonsectarian medical school located on the Jack and Pearl Resnick Campus in the Morris Park neighborhood of the borough of the Bronx of New York City...
- ♦ Violetta Iotsova, PhD, (11) Bristol-Myers Squibb Pharmaceutical Research Institute
- ♦ Raina N. Ikonomova PhD, (4) not active in research
- ♦ Svetlana I. Gramatikova, PhD, (9) Burnham Institute for Medical ResearchBurnham Institute for Medical ResearchThe Sanford-Burnham Medical Research Institute, previously Burnham Institute for Medical Research, is a non-profit medical research institute with locations in La Jolla, California, Orlando, Florida, and Santa Barbara, California...
- ♦ Georgi Milchev, PhD, (13) Inst. of Mol. Biol., Bulgarian Academy of SciencesBulgarian Academy of SciencesThe Bulgarian Academy of Sciences is the National Academy of Bulgaria, established in 1869. The Academy is autonomous and has a Society of Academicians, Correspondent Members and Foreign Members...
- ♦ Ivan I. Todorov, (221) PhD, City of Hope National Medical CenterCity of Hope National Medical CenterCity of Hope National Medical Center, is a private, not-for-profit clinical research center, hospital and graduate medical school located in Duarte, California, United States...
- ♦ Milko M. Kermekchiev, PhD (12) Washington University in St. LouisWashington University in St. LouisWashington University in St. Louis is a private research university located in suburban St. Louis, Missouri. Founded in 1853, and named for George Washington, the university has students and faculty from all fifty U.S. states and more than 110 nations...
- ♦ Radka Philipova, PhD, (14) Newcastle University
- ♦ Nikolai Zhelev, PhD, (28) University of Abertay DundeeUniversity of Abertay DundeeThe University of Abertay Dundee, usually known simply as Abertay University, is a modern university in Dundee, Scotland.- History :The University of Abertay Dundee was created in 1994, under government legislation granting the title University to the Dundee Institute of Technology...
- ♦ Krasimir Y. Yankulov, PhD (19) University of TorontoUniversity of TorontoThe University of Toronto is a public research university in Toronto, Ontario, Canada, situated on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada...
- ♦ Alex P. Vassilev, PhD, (105) University of AarhusUniversity of AarhusAarhus University , located in the city of Aarhus, Denmark, is Denmark's second oldest and second largest university...
- ♦ Luchezar K. Karagyozov, PhD, (15) Friedrich Schiller University of JenaFriedrich Schiller University of JenaFriedrich Schiller University of Jena , is a public research university located in Jena, Thuringia, Germany....
- ♦ Iveta D. Kalcheva, PhD (14) UCSD Cancer Center UCSD Medical CenterUCSD Medical CenterUC San Diego Health System is an academic health system in San Diego and has been in operation since 1966. It is composed of UC San Diego Medical Center, Thornton Hospital, Moores Cancer Center, Shiley Eye Center, Sulpizio Cardiovascular Center and Jacobs Medical Center , as well as other primary...
- ♦ Irina Stancheva, PhD, (22) University of EdinburghUniversity of EdinburghThe University of Edinburgh, founded in 1583, is a public research university located in Edinburgh, the capital of Scotland, and a UNESCO World Heritage Site. The university is deeply embedded in the fabric of the city, with many of the buildings in the historic Old Town belonging to the university...
- ♦ Oleg I. Georgiev, PhD, (99) Institut für Molekularbiologie, Universität Zürich
- ♦ Peter Milev, MD, PhD, (17) University of IowaUniversity of IowaThe University of Iowa is a public state-supported research university located in Iowa City, Iowa, United States. It is the oldest public university in the state. The university is organized into eleven colleges granting undergraduate, graduate, and professional degrees...
- ♦ Kosi Gramatikoff, PhD, (9) Burnham Institute for Medical ResearchBurnham Institute for Medical ResearchThe Sanford-Burnham Medical Research Institute, previously Burnham Institute for Medical Research, is a non-profit medical research institute with locations in La Jolla, California, Orlando, Florida, and Santa Barbara, California...
External links
- Bulgarian Academy of SciencesBulgarian Academy of SciencesThe Bulgarian Academy of Sciences is the National Academy of Bulgaria, established in 1869. The Academy is autonomous and has a Society of Academicians, Correspondent Members and Foreign Members...
official website