Arsenicum album
Encyclopedia
Arsenicum album is a frequently-used homeopathic
Homeopathy
Homeopathy is a form of alternative medicine in which practitioners claim to treat patients using highly diluted preparations that are believed to cause healthy people to exhibit symptoms that are similar to those exhibited by the patient...

 substance consisting of arsenic trioxide
Arsenic trioxide
Arsenic trioxide is the inorganic compound with the formula As2O3. This commercially important oxide of arsenic is the main precursor to other arsenic compounds, including organoarsenic compounds. Approximately 50,000 tonnes are produced annually...

. It is used by homeopaths to treat a range of symptoms that include digestive disorders (especially food poisoning), insomnia
Insomnia
Insomnia is most often defined by an individual's report of sleeping difficulties. While the term is sometimes used in sleep literature to describe a disorder demonstrated by polysomnographic evidence of disturbed sleep, insomnia is often defined as a positive response to either of two questions:...

, allergies, anxiety
Anxiety
Anxiety is a psychological and physiological state characterized by somatic, emotional, cognitive, and behavioral components. The root meaning of the word anxiety is 'to vex or trouble'; in either presence or absence of psychological stress, anxiety can create feelings of fear, worry, uneasiness,...

, depression
Depression (mood)
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behaviour, feelings and physical well-being. Depressed people may feel sad, anxious, empty, hopeless, helpless, worthless, guilty, irritable, or restless...

, and obsessiveā€“compulsive disorder, and it has been studied as a possible treatment for arsenic poisoning
Arsenic poisoning
Arsenic poisoning is a medical condition caused by increased levels of the element arsenic in the body. Arsenic interferes with cellular longevity by allosteric inhibition of an essential metabolic enzyme...

. The arsenic oxide in a homeopathic preparation is highly diluted, and so is considered generally safe, although rare reports of arsenic poisoning from poorly-prepared homeopathic treatments sold in India have been reported. When properly prepared, however, the extreme dilutions, typically to at least 1 in 1024, or 12C in homeopathic notation, mean that it is extremely statistically unlikely that any pill contains even a molecule of the original arsenic used. While some small, unblinded studies have claimed an effect on reducing arsenic toxicity, they do not recommend its large-scale use, and studies of homeopathic remedies have been shown to generally have problems that prevent them from being considered unambiguous evidence. There is no known mechanism for how arsenicum album could remove arsenic from a body, and there is insufficient evidence for it to be considered effective medicine (for any condition) by the scientific community
Scientific community
The scientific community consists of the total body of scientists, its relationships and interactions. It is normally divided into "sub-communities" each working on a particular field within science. Objectivity is expected to be achieved by the scientific method...

.

Use in homeopathy

According to a popular homeopathy guide, arsenicum album is one of the fifteen most important remedies in homeopathy. In classical homeopathy, people are grouped by "constitutional type" named after the homeopathic remedy applied, on the argument that people with similar "body shapes and personalities" suffer from the same type of diseases. "Arsen. alb." types are "tense, restless ambitious individuals" with a tendency toward hypochondriasis, pessimism, need for reassurance, and a meticulous attention to neatness and detail.

For homeopathic use, arsenicum album is prepared by separating arsenic from iron
Iron
Iron is a chemical element with the symbol Fe and atomic number 26. It is a metal in the first transition series. It is the most common element forming the planet Earth as a whole, forming much of Earth's outer and inner core. It is the fourth most common element in the Earth's crust...

 (as in arsenopyrite
Arsenopyrite
Arsenopyrite is an iron arsenic sulfide . It is a hard metallic, opaque, steel grey to silver white mineral with a relatively high specific gravity of 6.1. When dissolved in nitric acid, it releases elemental sulfur. When arsenopyrite is heated, it becomes magnetic and gives off toxic fumes...

), cobalt
Cobalt
Cobalt is a chemical element with symbol Co and atomic number 27. It is found naturally only in chemically combined form. The free element, produced by reductive smelting, is a hard, lustrous, silver-gray metal....

, or nickel
Nickel
Nickel is a chemical element with the chemical symbol Ni and atomic number 28. It is a silvery-white lustrous metal with a slight golden tinge. Nickel belongs to the transition metals and is hard and ductile...

 by baking at high temperatures. The powder is then ground and diluted with lactose
Lactose
Lactose is a disaccharide sugar that is found most notably in milk and is formed from galactose and glucose. Lactose makes up around 2~8% of milk , although the amount varies among species and individuals. It is extracted from sweet or sour whey. The name comes from or , the Latin word for milk,...

. In the final dilution, there are normally no atoms of arsenic left. The final product is sold as tincture
Tincture
A tincture is an alcoholic extract or solution of a non-volatile substance . To qualify as a tincture, the alcoholic extract is to have an ethanol percentage of at least 40-60%...

s (liquid), tablets, pellets, or powder.

Key homeopathic uses include treating anxiety and "fear caused by insecurity", digestive disorders and mucosal inflammation, and ailments characterized symptomatically by burning pain. It was also used once for treatment of syphilis
Syphilis
Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum subspecies pallidum. The primary route of transmission is through sexual contact; however, it may also be transmitted from mother to fetus during pregnancy or at birth, resulting in congenital syphilis...

.

Research studies

Several studies have been done into Arsenicum album, however, homeopathic studies are known to have problems, such as evidence of bias, lack of rigour, and failure to blind the experimenters or subjects to which group is being analysed that prevent them from being considered definitive evidence for any effect. In addition, the ideas behind homeopathy are scientifically implausible and directly opposed to fundamental principles of natural science
Natural science
The natural sciences are branches of science that seek to elucidate the rules that govern the natural world by using empirical and scientific methods...

 and modern medicine, which means that poorly-conducted, small, or unblinded studies are not considered scientific proof of efficacy.

The authors of one unblinded study of mice poisoned with arsenic and then given Arsenicum album claimed statistically significant reductions were reported in biochemical markers of liver damage. "However, other scientists remain sceptical", and Andreas Gescher, a biochemical toxicologist interviewed by New Scientist
New Scientist
New Scientist is a weekly non-peer-reviewed English-language international science magazine, which since 1996 has also run a website, covering recent developments in science and technology for a general audience. Founded in 1956, it is published by Reed Business Information Ltd, a subsidiary of...

, said "This kind of study uses a dilution so high there is hardly anything there... Is it really possible?" and went on to say that he was "extremely skeptical".
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