ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor

ADP ribosylation factor

ADP Ribosylation Factors are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally...

 family

Family (biology)

In biological classification, family is* a taxonomic rank. Other well-known ranks are life, domain, kingdom, phylum, class, order, genus, and species, with family fitting between order and genus. As for the other well-known ranks, there is the option of an immediately lower rank, indicated by the...

 of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membrane

Biological membrane

A biological membrane or biomembrane is an enclosing or separatingmembrane that acts as a selective barrier, within or around a cell. It consists of a lipid bilayer with embedded proteins that may constitute close to 50% of membrane content...

s and transmembrane protein

Transmembrane protein

A transmembrane protein is a protein that goes from one side of a membrane through to the other side of the membrane. Many TPs function as gateways or "loading docks" to deny or permit the transport of specific substances across the biological membrane, to get into the cell, or out of the cell as...

 cargo. ARF6 has specifically been implicated in endocytosis

Endocytosis

Endocytosis is a process by which cells absorb molecules by engulfing them. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane...

 of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.
ARF6 can interact with βarrestin

Arrestin

Arrestins are a small family of proteins important for regulating signal transduction.-Function:Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors in the visual rhodopsin system by Hermann Kühn and co-workers and...

 upon receptor activation.

Interactions

Arf6 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with:

• Arrestin beta 1
  Arrestin beta 1
  Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.- Function :Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular...
  
  ,
• ARFIP2
  ARFIP2
  Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.-Interactions:ARFIP2 has been shown to interact with Arf6, ARF3, ARF5 and RAC1.-Further reading:...
  
  ,
• EXOC5
  EXOC5
  Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.-Further reading:...
  
  , and
• KIAA0090
  KIAA0090
  KIAA0090 is a human gene coding for a protein of unknown function. KIAA0090 has two aliases OTTHUMP00000002581 and RP1-43E13.1. The gene codes for multiple transcript variants which can localize to different subcellular compartments. KIAA0090 interacts with multiple effector proteins...
  
  ,
• Muscarinic acetylcholine receptor M3
  Muscarinic acetylcholine receptor M3
  The muscarinic acetylcholine receptor M3, also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor. It is encoded by the human gene CHRM3....
  
  .

Further reading

External links