Aaron Ciechanover
Encyclopedia
Aaron Ciechanover (born October 1, 1947) is an Israel
i biologist
, and Nobel laureate in Chemistry
.
, British mandate of Palestine, a year before the establishment of the State of Israel. His family had immigrated from Poland before the Second World War.
He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1982 from the Technion (the Israel Institute of Technology), in Haifa. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.
Ciechanover is a member of the Israel Academy of Sciences and Humanities
, the Pontifical Academy of Sciences
, and is a foreign associate of the United States National Academy of Sciences
.
In 2005, he was voted the co-31st-greatest Israeli of all time, in a poll by the Israeli news website Ynet
to determine whom the general public considered the 200 Greatest Israelis.. As one of Israel's first Nobel Laureates in Science, he is honored in playing a central role in the history of the State of Israel and in the History of the Technion - Israel Institute of Technology.
Israel
The State of Israel is a parliamentary republic located in the Middle East, along the eastern shore of the Mediterranean Sea...
i biologist
Biology
Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, origin, evolution, distribution, and taxonomy. Biology is a vast subject containing many subdivisions, topics, and disciplines...
, and Nobel laureate in Chemistry
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
.
Biography
Ciechanover was born in HaifaHaifa
Haifa is the largest city in northern Israel, and the third-largest city in the country, with a population of over 268,000. Another 300,000 people live in towns directly adjacent to the city including the cities of the Krayot, as well as, Tirat Carmel, Daliyat al-Karmel and Nesher...
, British mandate of Palestine, a year before the establishment of the State of Israel. His family had immigrated from Poland before the Second World War.
He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1982 from the Technion (the Israel Institute of Technology), in Haifa. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.
Ciechanover is a member of the Israel Academy of Sciences and Humanities
Israel Academy of Sciences and Humanities
The Israel Academy of Sciences and Humanities, based in Jerusalem, was set up in 1961 by the State of Israel to foster contact between scholars from the sciences and humanities in Israel, to advise the government on research projects of national importance, and to promote excellence. It comprises...
, the Pontifical Academy of Sciences
Pontifical Academy of Sciences
The Pontifical Academy of Sciences is a scientific academy of the Vatican, founded in 1936 by Pope Pius XI. It is placed under the protection of the reigning Supreme Pontiff. Its aim is to promote the progress of the mathematical, physical and natural sciences and the study of related...
, and is a foreign associate of the United States National Academy of Sciences
United States National Academy of Sciences
The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
.
In 2005, he was voted the co-31st-greatest Israeli of all time, in a poll by the Israeli news website Ynet
Ynet
Ynet is the most popular Israeli news and general content website. It is owned by the same conglomerate that operates Yediot Ahronot, the country's secondleading daily newspaper...
to determine whom the general public considered the 200 Greatest Israelis.. As one of Israel's first Nobel Laureates in Science, he is honored in playing a central role in the history of the State of Israel and in the History of the Technion - Israel Institute of Technology.
Publications
- Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
- Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
- Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
Awards
- In 2000, Ciechanover received the Albert Lasker Award for Basic Medical ResearchAlbert Lasker Award for Basic Medical ResearchThe Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease...
. - In 2003, he was awarded the Israel PrizeIsrael PrizeThe Israel Prize is an award handed out by the State of Israel and is largely regarded as the state's highest honor. It is presented annually, on Israeli Independence Day, in a state ceremony in Jerusalem, in the presence of the President, the Prime Minister, the Knesset chairperson, and the...
, for biology. - in 2004, he was awarded Nobel PrizeNobel PrizeThe Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...
in ChemistryChemistryChemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
for his discovery with Avram HershkoAvram HershkoAvram Hershko is a Hungarian-Israeli biochemist and Nobel laureate in Chemistry.-Biography:Born Herskó Ferenc in Karcag, Hungary, Hershko emigrated to Israel in 1950. Received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel...
and Irwin RoseIrwin RoseIrwin A. Rose is an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.-Biography:...
, of ubiquitinUbiquitinUbiquitin is a small regulatory protein that has been found in almost all tissues of eukaryotic organisms. Among other functions, it directs protein recycling.Ubiquitin can be attached to proteins and label them for destruction...
-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
External links
- Nobel Prize Lecture
- Website at the Technion
- http://gpu-ua.info/index.php?&id=246531&lang=en
- A video interview with Aaron Ciechanover
See also
- List of Israel Prize recipients
- List of Jewish Nobel laureates