ATP-binding motif
Encyclopedia
An ATP-Binding Motif is a specific sequence of protein
subunits (and hence genomic DNA
base pair
s) that promotes the attachment of ATP
to a target protein. An ATP binding site is a protein micro-environment where ATP is captured and hydrolyzed
to ADP, releasing energy that is utilized by the protein to "do work" by changing the protein shape and/or making the enzyme catalytically active. The same ATP binding motif is used in many proteins: hence a "motif" that is similar across a range of proteins. The genetic and functional similarity of such a motif demonstrates micro-evolution: proteins have co-opted the same binding sequence from other enzymes rather than developing them independently.
ATP binding sites, which may be representative of an ATP binding motif, are utilized on many proteins which perform function requiring an input of energy (from ATP). Such sites are located on active membrane transporters, Microtubule
subunits, flagellum
proteins, and various hydrolytic and proteolytic enzymes.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
subunits (and hence genomic DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
base pair
Base pair
In molecular biology and genetics, the linking between two nitrogenous bases on opposite complementary DNA or certain types of RNA strands that are connected via hydrogen bonds is called a base pair...
s) that promotes the attachment of ATP
Adenosine triphosphate
Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
to a target protein. An ATP binding site is a protein micro-environment where ATP is captured and hydrolyzed
Hydrolysis
Hydrolysis is a chemical reaction during which molecules of water are split into hydrogen cations and hydroxide anions in the process of a chemical mechanism. It is the type of reaction that is used to break down certain polymers, especially those made by condensation polymerization...
to ADP, releasing energy that is utilized by the protein to "do work" by changing the protein shape and/or making the enzyme catalytically active. The same ATP binding motif is used in many proteins: hence a "motif" that is similar across a range of proteins. The genetic and functional similarity of such a motif demonstrates micro-evolution: proteins have co-opted the same binding sequence from other enzymes rather than developing them independently.
ATP binding sites, which may be representative of an ATP binding motif, are utilized on many proteins which perform function requiring an input of energy (from ATP). Such sites are located on active membrane transporters, Microtubule
Microtubule
Microtubules are a component of the cytoskeleton. These rope-like polymers of tubulin can grow as long as 25 micrometers and are highly dynamic. The outer diameter of microtubule is about 25 nm. Microtubules are important for maintaining cell structure, providing platforms for intracellular...
subunits, flagellum
Flagellum
A flagellum is a tail-like projection that protrudes from the cell body of certain prokaryotic and eukaryotic cells, and plays the dual role of locomotion and sense organ, being sensitive to chemicals and temperatures outside the cell. There are some notable differences between prokaryotic and...
proteins, and various hydrolytic and proteolytic enzymes.