VAMP
Encyclopedia
Vesicle associated membrane proteins (VAMP) are a family of SNARE proteins
with similar structure, and are mostly involved in vesicle fusion
.
SNARE (protein)
SNARE proteins are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells....
with similar structure, and are mostly involved in vesicle fusion
Vesicle fusion
Vesicle fusion is the merging of a vesicle with other vesicles or a part of a cell membrane. In the latter case, it is the end stage of secretion from secretory vesicles, where their contents are expelled from the cell through exocytosis at the porosome...
.
- VAMP1VAMP1Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.-Further reading:...
and VAMP2VAMP2Vesicle-associated membrane protein 2 is a protein that in humans is encoded by the VAMP2 gene.-Interactions:VAMP2 has been shown to interact with STX4, SNAP-25, SNAP23, STX1A and RABAC1.-Further reading:...
proteins known as synaptobrevinSynaptobrevinSynaptobrevins are small integral membrane proteins of secretory vesicles with molecular weight of 18 kilodalton that are part of the vesicle-associated membrane protein family....
s are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator releaseExocytosisExocytosis , also known as 'The peni-cytosis', is the durable process by which a cell directs the contents of secretory vesicles out of the cell membrane...
.
- VAMP3VAMP3Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.-Interactions:VAMP3 has been shown to interact with* BCAP31,* BVES,* SNAP23,* STX4,* STX6.-Further reading:...
(known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosisExocytosisExocytosis , also known as 'The peni-cytosis', is the durable process by which a cell directs the contents of secretory vesicles out of the cell membrane...
as a constituent of secretory granules and secretory vesicles.
- VAMP5VAMP5Vesicle-associated membrane protein 5 also known as VAMP5 is a human gene which encodes a member of the synaptobrevin protein family.-Function:...
and VAMP7 (SYBL1SYBL1Vesicle-associated membrane protein 7 is a protein that in humans is encoded by the VAMP7 gene.- Function :VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor family...
) participate in constitutive exocytosis.- VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
- VAMP7 is found both in secretory granules and endosomes.
- VAMP8 (known as endobrevin) participates in endocytosisEndocytosisEndocytosis is a process by which cells absorb molecules by engulfing them. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane...
and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
- VAMP4VAMP4Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.-Interactions:VAMP4 has been shown to interact with AP1M1, STX6 and STX16.-Further reading:...
is involved in transport from the Golgi.