Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokine

Cytokine

Cytokines are small cell-signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used extensively in intercellular communication...

s with four α-helical

Alpha helix

A common motif in the secondary structure of proteins, the alpha helix is a right-handed coiled or spiral conformation, in which every backbone N-H group donates a hydrogen bond to the backbone C=O group of the amino acid four residues earlier...

 strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid

Amino acid

Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...

 motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand

Ligand

In coordination chemistry, a ligand is an ion or molecule that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from...

/cytokine interaction and others that are involved in signal transduction

Signal transduction

Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...

.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.

• The IL-2 receptor common gamma chain
  Common gamma chain
  The common gamma chain , also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor...
  
   (also known as CD132) is shared between:
  • IL-2 receptor
  • IL-4 receptor
  • IL-7 receptor
  • IL-9 receptor
  • IL-13 receptor
  • IL-15 receptor

• The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
  • GM-CSF receptor
  • IL-3 receptor
  • IL-5 receptor.

• The gp230 receptor common gamma chain
  Common gamma chain
  The common gamma chain , also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor...
  
   (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
  • IL-6 receptor
  • IL-11 receptor
  • Leukamia inhibitory factor receptor
  • Oncostatin M receptor
    Oncostatin M receptor
    Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.OSMR is a member of the type I cytokine receptor family...
    
    

Examples

Type I cytokine receptors include interleukin

Interleukin

Interleukins are a group of cytokines that were first seen to be expressed by white blood cells . The term interleukin derives from "as a means of communication", and "deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes"...

 receptors, colony stimulating factor receptors and other cytokine receptors

Colony stimulating factor receptors

• Erythropoietin receptor
  Erythropoietin receptor
  The erythropoietin receptor is a protein that in humans is encoded by the EPOR gene. EpoR is a 59 kDa peptide and is a member of the cytokine receptor family. EpoR pre-exists as dimers...
  
  
• GM-CSF receptor
• G-CSF receptor