Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M

Oncostatin M

Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor in both structure and function...

, that in humans is encoded by the OSMR gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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OSMR is a member of the type I cytokine receptor

Type I cytokine receptor

Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif in the extracellular portion...

 family. This protein heterodimerizes with interleukin 6 signal transducer

Glycoprotein 130

Glycoprotein 130 is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family...

 to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor

IL31RA

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.-Further reading:...

, and thus transduces oncostatin M

Oncostatin M

Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor in both structure and function...

 and interleukin 31

Interleukin 31

Interleukin-31 also known as IL-31 is a protein that in humans is encoded by the IL31 gene.- Function :IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells . The structure of IL-31 places it in the IL-6 family of cytokines...

 induced signaling events.

Clinical significance

The oncostatin M receptor is associated with primary cutaneous amyloidosis

Primary cutaneous amyloidosis

Primary cutaneous amyloidosis is a form of amyloidosis associated with oncostatin M receptor. This type of amyloidosis has been divided into the following types:* Macular amyloidosis* Lichen amyloidosis* Nodular amyloidosis...

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