Transcription Factor II B
Encyclopedia
Transcription factor II B (TFIIB) is one of several general transcription factor
s that make up the RNA polymerase II
preinitiation complex
. It is encoded by the gene.
Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID
and IIA. The protein serves as a bridge between IID, the factor that initially recognizes the promoter sequence, and RNA polymerase II. It is involved in the selection of the transcription start site: mutations in TFIIB cause a shift in the transcription start site.
with CREB-binding protein, GTF2H4
, TATA-binding protein, POLR2A
, TAF11
, GTF2F1
and C-jun
.
General transcription factor
General transcription factors or basal transcription factors are protein transcription factors that have been shown to be important in the transcription of class II genes to mRNA templates...
s that make up the RNA polymerase II
RNA polymerase II
RNA polymerase II is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase...
preinitiation complex
Preinitiation complex
The preinitiation complex is a large complex of proteins that is necessary for the transcription of protein-coding genes in eukaryotes...
. It is encoded by the gene.
Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID
Transcription Factor II D
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins...
and IIA. The protein serves as a bridge between IID, the factor that initially recognizes the promoter sequence, and RNA polymerase II. It is involved in the selection of the transcription start site: mutations in TFIIB cause a shift in the transcription start site.
Interactions
Transcription Factor II B has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with CREB-binding protein, GTF2H4
GTF2H4
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.-Interactions:GTF2H4 has been shown to interact with MED21, GTF2F1, TATA binding protein, XPB, POLR2A and Transcription Factor II B....
, TATA-binding protein, POLR2A
POLR2A
DNA-directed RNA polymerase II subunit RPB1 is an enzyme that in humans is encoded by the POLR2A gene.-Interactions:POLR2A has been shown to interact with Transcription elongation regulator 1, CREB-binding protein, BRCA1, GTF2H4, TATA-binding protein, PCAF, GTF2F1, SUPT5H, Transcription Factor II...
, TAF11
TAF11
Transcription initiation factor TFIID subunit 11 is a protein that in humans is encoded by the TAF11 gene.-Interactions:TAF11 has been shown to interact with TAF15, TAF13, TATA binding protein, GTF2F1, POLR2A and Transcription Factor II B....
, GTF2F1
GTF2F1
General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.-Interactions:GTF2F1 has been shown to interact with TAF1, HNRPU, GTF2H4, CTDP1, TATA binding protein, POLR2A, MED21, TAF11, Serum response factor and Transcription Factor II B.-Further reading:...
and C-jun
C-jun
c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...
.