Tracazolate
Encyclopedia
Tracazolate is an anxiolytic
drug
which is used in scientific research. It is a pyrazolopyridine
derivative, most closely related to pyrazolopyrimidine
drugs such as zaleplon
, and is one of a structurally diverse group of drugs known as the nonbenzodiazepine
s which act at the same receptor targets as benzodiazepine
s but have distinct chemical structures.
Tracazolate has primarily anxiolytic
and anticonvulsant
effects, with sedative
and muscle relaxant
effects only appearing at higher doses. It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
drug
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
which is used in scientific research. It is a pyrazolopyridine
Pyrazolopyridine
The pyrazolopyridines are a chemical class of anxiolytic drugs which act as positive allosteric modulators of the GABAA receptor at the barbiturate binding site. They include the following compounds:* Cartazolate * Etazolate * ICI-190,622...
derivative, most closely related to pyrazolopyrimidine
Pyrazolopyrimidine
Pyrazolopyrimidine is a heterocyclic chemical compound with the molecular formula C6H5N3. It forms the central core of a variety of more complex chemical compounds including some pharmaceuticals and pesticides.-Pharmaceuticals:...
drugs such as zaleplon
Zaleplon
Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. In terms of adverse effects zaleplon appears to offer little improvement compared to both benzodiazepines and other non-benzodiazepine Z-drugs.Sonata is manufactured by...
, and is one of a structurally diverse group of drugs known as the nonbenzodiazepine
Nonbenzodiazepine
The nonbenzodiazepines, also called benzodiazepine-like drugs, are a class of psychoactive drugs pharmacologically resembling the benzodiazepines, with similar benefits, side effects and risks, despite having dissimilar or entirely different chemical structures.-Classes:There are currently three...
s which act at the same receptor targets as benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
s but have distinct chemical structures.
Tracazolate has primarily anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
and anticonvulsant
Anticonvulsant
The anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and in the treatment of neuropathic pain. The goal of an...
effects, with sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
and muscle relaxant
Muscle relaxant
A muscle relaxant is a drug which affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeutic groups: neuromuscular blockers and spasmolytics...
effects only appearing at higher doses. It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.