The Toronto, Hamilton and Buffalo Railway was a railway based in Hamilton

Hamilton, Ontario

Hamilton is a port city in the Canadian province of Ontario. Conceived by George Hamilton when he purchased the Durand farm shortly after the War of 1812, Hamilton has become the centre of a densely populated and industrialized region at the west end of Lake Ontario known as the Golden Horseshoe...

 that ran in Southern Ontario

Southern Ontario

Southern Ontario is a region of the province of Ontario, Canada that lies south of the French River and Algonquin Park. Depending on the inclusion of the Parry Sound and Muskoka districts, its surface area would cover between 14 to 15% of the province. It is the southernmost region of...

 from 1894 to 1987. It never reached the other two cities in its name, although it did have branch lines extending to Dunnville

Dunnville, Ontario

Dunnville is an unincorporated community of 6,000 people located near the mouth of the Grand River in Haldimand County, Ontario, Canada, near the historic Talbot Trail...

 and Port Maitland

Port Maitland, Ontario

thumb|Grand River, OntarioPort Maitland is a small community in the province of Ontario Canada.It is on the North shore of Lake Erie, at the mouth of the Grand River.At one time a canal connected the Welland Canal to the Grand River....

.
The railway was originally chartered in 1884 by the Ontario Legislative Assembly to run from Toronto

Toronto

Toronto is the provincial capital of Ontario and the largest city in Canada. It is located in Southern Ontario on the northwestern shore of Lake Ontario. A relatively modern city, Toronto's history dates back to the late-18th century, when its land was first purchased by the British monarchy from...

 to the International Railway Bridge

International Railway Bridge

The International Railway Bridge carries a railway line across the Niagara River between Fort Erie, Ontario and Buffalo, New York. It was built in 1873 for the International Bridge Company by Casimir Stanislaus Gzowski and D.L...

, connecting with local lines to Buffalo

Buffalo, New York

Buffalo is the second most populous city in the state of New York, after New York City. Located in Western New York on the eastern shores of Lake Erie and at the head of the Niagara River across from Fort Erie, Ontario, Buffalo is the seat of Erie County and the principal city of the...

. The original charter forbade the company any attempt to merge with, lease from, sell to, or pool with any other railway.