Tipepidine
Encyclopedia
Tipepidine was discovered in the 1950s. Under the trade-names (Bithiodine, Sotal, Antupex, Asverin) is used as a centrally-acting cough suppressant of the opioid type. It is a member of the thiambutene
Thiambutene
The Thiambutenes are a family of opioid analgesic drugs developed at the British research laboratory of Burroughs-Wellcome in the late 1940s.The parent compound thiambutene has no analgesic effects, but several compounds from this group are analgesics with around the same potency as...

 series of open-chain (methadone
Methadone
Methadone is a synthetic opioid, used medically as an analgesic and a maintenance anti-addictive for use in patients with opioid dependency. It was developed in Germany in 1937...

-related) synthetic opioids, which include Ohton (dimethylthiambutene
Dimethylthiambutene
Dimethylthiambutene is an opioid analgesic drug, most often used in veterinary medicine in Japan and to a lesser extent in other countries in the region and around the world...

), a strong narcotic analgesic used particularly in veterinary medicine in Japan and other East Asian countries. It was developed in Japan in 1959 and is used as the citrate and hibenzate salts. The usual dose is 20 mg every 4–6 hours. Its relative weakness and other properties make it a drug which is not controlled in most countries or internationally.
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