Thyrotropin-releasing hormone receptor
Encyclopedia
The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor
which binds the tripeptide thyrotropin releasing hormone. The TRHR are found in the brain
and when bound by TRH result act through phospholipase C
to increase intracellular
inositol trisphosphate.
G protein-coupled receptor
G protein-coupled receptors , also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors , comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal...
which binds the tripeptide thyrotropin releasing hormone. The TRHR are found in the brain
Brain
The brain is the center of the nervous system in all vertebrate and most invertebrate animals—only a few primitive invertebrates such as sponges, jellyfish, sea squirts and starfishes do not have one. It is located in the head, usually close to primary sensory apparatus such as vision, hearing,...
and when bound by TRH result act through phospholipase C
Phospholipase C
Phosphoinositide phospholipase C is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. In general, this enzyme is denoted as Phospholipase C, although three other families of phospholipase C enzymes have been identified in bacteria and in...
to increase intracellular
Intracellular
Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...
inositol trisphosphate.