Hydrogen bonding interaction in protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

s plays a crucial role in protein folding, dynamics and function. A few percent of hydrogen bonds connect distant amino acid

Amino acid

Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...

 residues and are not involved in secondary structure

Secondary structure

In biochemistry and structural biology, secondary structure is the general three-dimensional form of local segments of biopolymers such as proteins and nucleic acids...

 stabilization. These hydrogen bonds have special role in the proteins and called tertiary hydrogen bonds . Tertiary hydrogen bonds can be viewed as a network enabling fast and specific (directional) communication over the whole protein.

Definition

1. Hydrogen bond
   Hydrogen bond
   A hydrogen bond is the attractive interaction of a hydrogen atom with an electronegative atom, such as nitrogen, oxygen or fluorine, that comes from another molecule or chemical group. The hydrogen must be covalently bonded to another electronegative atom to create the bond...
   
   s that stabilize the tertiary structure
   Tertiary structure
   In biochemistry and molecular biology, the tertiary structure of a protein or any other macromolecule is its three-dimensional structure, as defined by the atomic coordinates.-Relationship to primary structure:...
   
    of the protein
   Protein
   Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
   
   s
2. Off-diagonal points in the HB plot
   HB plot
   Knowledge of the relationship between a protein's structure and its dynamic behavior is essential for understanding protein function. The description of a protein three dimensional structure as a network of hydrogen bonding interactions was introduced as a tool for exploring protein structure and...