Tadamitsu Kishimoto
Encyclopedia
Dr. is a Japanese immunologist known for research on IgM
and cytokines, most famously, interleukin 6
.
He did postdoctoral work under Kimishige Ishizaka
, the discoverer of IgE
at Johns Hopkins University
.
He is listed by the Institute for Scientific Information
(ISI) as a highly cited biologist
and he is also in the top ten of h-index
of living biologists.
in 1939, was President of Osaka University
from 1997 to 2003 and a Member, Council for Science and Technology Policy, Cabinet office from 2004 to 2006. He is now Professor, Graduate School of Frontier Biosciences, Osaka University. He was Dean, Professor and Chairman of Department of Medicine at Osaka University Medical School from which he graduated in 1964. He is currently Japan's leading scientist in the field of life science, specifically in immunology and has made fundamental contributions to the understanding of cytokine functions through series of his studies on IL-6, its receptor system, and transcription factors. He has developed anti-IL6 receptor therapy for several immune disorders including Castleman’s disease, rheumatoid arthritis
and juvenile idiopathic arthritis
.
He has received numerous awards, including the Imperial Prize of the Japan Academy
in 1992, the Sandoz Prize for Immunology from the International Union of Immunological Society in 1992 and the Avery-Landsteiner Prize from the German Immunology Society in 1996. In 1998, he was awarded the Order of Culture
from Emperor. He was awarded Robert Koch Gold Medal in 2003, Honorary Life Time Achievement Awards from International Cytokine Society in 2006 and the Crafoord Award from the Royal Swedish Academy of Sciences in 2009. He has been elected a Foreign Associate of the US National Academy of Sciences in 1991, a member of the Japan Academy in 1995 and a member of Deutsche Akademine der Naturforscher Leopoldina in 2005. He served as a president of the International Immunopharmacology Society, International Cytokine Society and the Japanese Immunology Society. He is an honorary member in American Association of Immunologists and American Society of Hematology.
s. Furthermore, he demonstrated that the activity for inducing IgG and IgE antibodies could be separated. Later, this finding led to the discovery of the dichotomy of helper T cells, Th1 and Th2.
On the basis of these early studies, Dr. Kishimoto discovered and cloned interleukin-6 and its receptor and delineated the signaling pathway used by IL-6 and the set of related cytokines that utilize gp-130, which he also discovered. He identified the transcription factors NF-IL-6 and STAT3
, both central to the action of IL-6. He further discovered a family of suppressors of cytokine signaling, the SOCS molecules, that are key regulators of cytokine function.
He demonstrated the involvement of IL-6 in the pathogenesis of cardiac myxomas, multiple myeloma
, Castleman’s disease, rheumatoid arthritis, Crohn’s disease and juvenile idiopathic arthritis (JIA). He identified IL-6 as a hepatocyte stimulating factor which induces acute phase reactions.
He prepared an monoclonal anti-IL-6 receptor antibody that was subsequently humanized and has been shown to be of great therapeutic value in a series of autoinflammatory diseases including Castleman's Disease, rheumatoid arthritis and juvenile idiopathic arthritis.
His work has dominated the field of proinflammatory cytokines and has established paradigms for the study of all of cytokine biology, ranging from discovery of the cytokine and its receptor, through signaling and transcriptional mechanisms, to the utilization of such knowledge to develop highly effective therapeutics.
A series of his IL-6 studies for 35 years since 1973 have been highly appreciated; He was ranked as the world’s 8th-most-cited researchers between 1983 and 2002 and he is in the top ten of h-index of living biologists.
IGM
IGM as an acronym or abbreviation can refer to:* Immunoglobulin M , the primary antibody against A and B antigens on red blood cells* International Grandmaster, a chess ranking* intergalactic medium* Intragroup medium - see: Intracluster medium...
and cytokines, most famously, interleukin 6
Interleukin 6
Interleukin-6 is a protein that in humans is encoded by the IL6 gene.IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma, especially burns or other...
.
He did postdoctoral work under Kimishige Ishizaka
Kimishige Ishizaka
Dr is a Japanese scientist who discovered the antibody class IgE in 1966. His work has been regarded as a major breakthrough in the understanding of allergy. He was awarded the 1973 Gairdner Foundation International Award and the 2000 Japan Prize for his work in immunology. He was elected a member...
, the discoverer of IgE
IGE
IGE was one of the largest services company buying and selling virtual currencies and accounts for MMORPG. During its peak time, it had offices in Los Angeles, China , and headquarters & customer service centre in Hong Kong. IGE was one of the main monopoly in virtual economy services, also known...
at Johns Hopkins University
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...
.
He is listed by the Institute for Scientific Information
Institute for Scientific Information
The Institute for Scientific Information was founded by Eugene Garfield in 1960. It was acquired by Thomson Scientific & Healthcare in 1992, became known as Thomson ISI and now is part of the Healthcare & Science business of the multi-billion dollar Thomson Reuters Corporation.ISI offered...
(ISI) as a highly cited biologist
Biologist
A biologist is a scientist devoted to and producing results in biology through the study of life. Typically biologists study organisms and their relationship to their environment. Biologists involved in basic research attempt to discover underlying mechanisms that govern how organisms work...
and he is also in the top ten of h-index
H-index
The h-index is an index that attempts to measure both the productivity and impact of the published work of a scientist or scholar. The index is based on the set of the scientist's most cited papers and the number of citations that they have received in other publications...
of living biologists.
Life
Tadamitsu Kishimoto, who was born in OsakaOsaka
is a city in the Kansai region of Japan's main island of Honshu, a designated city under the Local Autonomy Law, the capital city of Osaka Prefecture and also the biggest part of Keihanshin area, which is represented by three major cities of Japan, Kyoto, Osaka and Kobe...
in 1939, was President of Osaka University
Osaka University
, or , is a major national university located in Osaka, Japan. It is the sixth oldest university in Japan as the Osaka Prefectural Medical College, and formerly one of the Imperial Universities of Japan...
from 1997 to 2003 and a Member, Council for Science and Technology Policy, Cabinet office from 2004 to 2006. He is now Professor, Graduate School of Frontier Biosciences, Osaka University. He was Dean, Professor and Chairman of Department of Medicine at Osaka University Medical School from which he graduated in 1964. He is currently Japan's leading scientist in the field of life science, specifically in immunology and has made fundamental contributions to the understanding of cytokine functions through series of his studies on IL-6, its receptor system, and transcription factors. He has developed anti-IL6 receptor therapy for several immune disorders including Castleman’s disease, rheumatoid arthritis
Rheumatoid arthritis
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...
and juvenile idiopathic arthritis
Juvenile idiopathic arthritis
Juvenile idiopathic arthritis is the most common form of persistent arthritis in children. JIA is a subset of arthritis seen in childhood, which may be transient and...
.
He has received numerous awards, including the Imperial Prize of the Japan Academy
Imperial Prize of the Japan Academy
The was a prestigious honor conferred by the Imperial Academy from 1911 through 1945. The award was presented to non-members in recognition of their academic theses, books, and achievements....
in 1992, the Sandoz Prize for Immunology from the International Union of Immunological Society in 1992 and the Avery-Landsteiner Prize from the German Immunology Society in 1996. In 1998, he was awarded the Order of Culture
Order of Culture
The is a Japanese order, established on February 11, 1937. The order has one class only, and may be awarded to men and women for contributions to Japan's art, literature or culture; recipients of the order also receive an annuity for life...
from Emperor. He was awarded Robert Koch Gold Medal in 2003, Honorary Life Time Achievement Awards from International Cytokine Society in 2006 and the Crafoord Award from the Royal Swedish Academy of Sciences in 2009. He has been elected a Foreign Associate of the US National Academy of Sciences in 1991, a member of the Japan Academy in 1995 and a member of Deutsche Akademine der Naturforscher Leopoldina in 2005. He served as a president of the International Immunopharmacology Society, International Cytokine Society and the Japanese Immunology Society. He is an honorary member in American Association of Immunologists and American Society of Hematology.
IL-6
In the early 1970s, Dr. Kishimoto discovered the activity inducing antibody production in culture supernatants of T cellT cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
s. Furthermore, he demonstrated that the activity for inducing IgG and IgE antibodies could be separated. Later, this finding led to the discovery of the dichotomy of helper T cells, Th1 and Th2.
On the basis of these early studies, Dr. Kishimoto discovered and cloned interleukin-6 and its receptor and delineated the signaling pathway used by IL-6 and the set of related cytokines that utilize gp-130, which he also discovered. He identified the transcription factors NF-IL-6 and STAT3
STAT3
Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor which in humans is encoded by the STAT3 gene.- Function :The protein encoded by this gene is a member of the STAT protein family...
, both central to the action of IL-6. He further discovered a family of suppressors of cytokine signaling, the SOCS molecules, that are key regulators of cytokine function.
He demonstrated the involvement of IL-6 in the pathogenesis of cardiac myxomas, multiple myeloma
Multiple myeloma
Multiple myeloma , also known as plasma cell myeloma or Kahler's disease , is a cancer of plasma cells, a type of white blood cell normally responsible for the production of antibodies...
, Castleman’s disease, rheumatoid arthritis, Crohn’s disease and juvenile idiopathic arthritis (JIA). He identified IL-6 as a hepatocyte stimulating factor which induces acute phase reactions.
He prepared an monoclonal anti-IL-6 receptor antibody that was subsequently humanized and has been shown to be of great therapeutic value in a series of autoinflammatory diseases including Castleman's Disease, rheumatoid arthritis and juvenile idiopathic arthritis.
His work has dominated the field of proinflammatory cytokines and has established paradigms for the study of all of cytokine biology, ranging from discovery of the cytokine and its receptor, through signaling and transcriptional mechanisms, to the utilization of such knowledge to develop highly effective therapeutics.
A series of his IL-6 studies for 35 years since 1973 have been highly appreciated; He was ranked as the world’s 8th-most-cited researchers between 1983 and 2002 and he is in the top ten of h-index of living biologists.
Honors and awards
- Behring-Kitasato Prize, 1982
- Osaka Science Prize, 1983
- Erwin von Bälz Prize, 1986
- Takeda Prize, 1988
- Asahi Prize, 1988
- Prize of The Japanese Medical Association, 1990
- Person of Cultural Merits, Japan 1990
- Foreign Associate, The US National Academy of Science, 1991
- Scientific Achievement Award from the International Association of Allergology and Clinical Immunology, 1991
- Honorary Member, the American Association of Immunologists, 1992
- Imperial Prize from the Japan Academy, 1992
- Sandoz Prize for Immunology from International Union of Immunology Society, 1992
- Honorary Citizen, Tondabayashi City, 1992
- Member, the Japan Academy, 1995
- The Avery-Landsteiner Prize from the German Immunology Society, 1996
- Foreign Associate member, the Institute of Medicine of the National Academy of Science, USA, 1997
- Honorary member, the American Society of Hematology,1997
- The Order of Culture from Emperor, 1998
- The Donald Seldin Award from the International Society of Nephrology, 1999
- ISI Citation Laureate AwardThomson Reuters Citation LaureatesThomson Reuters Citation Laureates is a list of candidates considered likely to win the Nobel Prize in their respective field. The candidates are so named based on the impact of their published research. The list of awardees is announced annually prior to the Nobel Prize ceremonies of that...
, 2000 - Doctor Honoris Causa, Universidad Technologica de Santiago, UTESA, 2001
- Honorary Member, International Association of Dental Research, 2001
- Honorary Professor, the fourth Military Medical University, Xi’an, China, 2002
- Honorary Member, World Innovation Foundation, 2002
- Doctor of Science, Honoris Causa, Mahidol University, 2003
- Robert Koch Gold Medal, 2003
- Clemens von Pirquet Distinguished Professor, Medicine and Immunology, University California, Davis, 2004
- Member, Deutsche Akademie der Naturforscher Leopoldina, 2005
- Honorary Lifetime Achievement Awards, International Cytokine Society, 2006
- 7th International Award of the Japan Rheumatism Foundation, 2008
- The Crafoord Prize from the Royal Swedish Academy of Sciences, 2009
- Japan PrizeJapan Prizeis awarded to people from all parts of the world whose "original and outstanding achievements in science and technology are recognized as having advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind."- Explanation :...
, 2011