TRIM62
Encyclopedia
TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1), is a protein in the tripartite motif family
. In human it is encoded by the gene TRIM62. TRIM62 is involved in the morphogenesis
of the mammary gland
, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer
.
Tripartite motif family
-Function:Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses...
. In human it is encoded by the gene TRIM62. TRIM62 is involved in the morphogenesis
Morphogenesis
Morphogenesis , is the biological process that causes an organism to develop its shape...
of the mammary gland
Mammary gland
A mammary gland is an organ in mammals that produces milk to feed young offspring. Mammals get their name from the word "mammary". In ruminants such as cows, goats, and deer, the mammary glands are contained in their udders...
, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer
Breast cancer
Breast cancer is cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas; those originating from lobules are known as lobular carcinomas...
.