Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

The protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 encoded by this gene is thought to be a transcriptional

Transcription (genetics)

Transcription is the process of creating a complementary RNA copy of a sequence of DNA. Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA by the action of the correct enzymes...

 corepressor

Corepressor (genetics)

In molecular genetics, a corepressor is a substance that inhibits the expression of genes. A corepressor downregulates the expression of genes not through direct interaction with a gene promoter , but rather indirectly through interaction with repressor proteins that in turn bind to the...

. However unlike the related TIF1-α

TRIM24

Tripartite motif-containing 24 also known as transcriptional intermediary factor 1α is a protein that, in humans, is encoded by the TRIM24 gene.- Function :...

 and TIF1-β

TRIM28

Tripartite motif-containing 28 also known as transcriptional intermediary factor 1β is a protein that in humans is encoded by the TRIM24 gene.- Function :...

 proteins, few transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

s such as Smad4 that interact with TIF1-γ have been identified.

Structure

The protein is a member of the tripartite motif family

Tripartite motif family

-Function:Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses...

. This motif includes three zinc-binding domains

Zinc finger

Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...

:

• RING
  RING finger domain
  In molecular biology, a RING finger domain is a protein structural domain of zinc finger type which contains a Cys3HisCys4 amino acid motif which binds two zinc cations. This protein domain contains from 40 to 60 amino acids...
  
  
• B-box type 1 zinc finger
• B-box type 2 zinc finger

and a coiled-coil

Coiled coil

A coiled coil is a structural motif in proteins, in which 2-7 alpha-helices are coiled together like the strands of a rope . Many coiled coil type proteins are involved in important biological functions such as the regulation of gene expression e.g. transcription factors...

region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.