Tumor necrosis factor ligand superfamily member 14 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the TNFSF14 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. TNFSF14 has also been designated as CD258, as well as LIGHT.

Interactions

TNFSF14 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with TNFRSF14

TNFRSF14

Tumor necrosis factor receptor superfamily member 14 is a protein that in humans is encoded by the TNFRSF14 gene. It is also known as "herpesvirus entry mediator" .-Interactions:...

, TNFRSF6B

TNFRSF6B

Tumor necrosis factor receptor superfamily member 6B is a protein that in humans is encoded by the TNFRSF6B gene.-Interactions:TNFRSF6B has been shown to interact with TNFSF14 and Fas ligand.-External links:*...

, BIRC2

BIRC2

Baculoviral IAP repeat-containing protein 2 is a protein that in humans is encoded by the BIRC2 gene.-Interactions:...

, TRAF2

TRAF2

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.-Interactions:TRAF2 has been shown to interact with BCL10, CD30, CFLAR, IKK2, MAP3K7IP2, CD137, Caveolin 1, CD27, TNFRSF13B, TANK-binding kinase 1, TRAF1, CD40, UBE2N, MAP3K14, MAP4K2, CASP8AP2, HIVEP3,...

 and TRAF3

TRAF3

TNF receptor-associated factor 3 is a protein that in humans is encoded by the TRAF3 gene.-Interactions:TRAF3 has been shown to interact with CD30, CD27, Lymphotoxin beta receptor, Nucleoporin 62, CD40, TNFSF14, RANK, Caspase 3 and TANK....

.

Role in Herpes Simplex Virus

Similar to how CD4

CD4

CD4 is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984...

 is the primary mediating receptor in HIV infection, the HSV

HSV

HSV may refer to:* Herpes simplex virus* HSV color space * HSV television station, the Melbourne station of Australia's Seven television network...

 glycoprotein (gD

GD

-Computing:* GD Graphics Library for dynamically manipulating images* GD-ROM, storage media for the Sega Dreamcast* .gd, the country code top-level domain for Grenada-Science and medicine:* Gadolinium , a chemical element...

) binds to the HVEM receptor which is demanded by TNFSF14/LIGHT lowering the ability for LIGHT to activate the NFκB pathway. NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting caspase 8

Caspase 8

Caspase 8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase 3.CASP8 orthologs have been identified in numerous mammals for which complete genome data are available...

. When gD from HSV binds to HVEM, LIGHT is non-competitively inhibited from binding, encouraging apoptosis in the infected cell.

External links