TIMP3
Encyclopedia
Metalloproteinase inhibitor 3 is an protein
that in humans is encoded by the TIMP3 gene
.
This gene belongs to the tissue inhibitor of metalloproteinases
gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinase
s, a group of peptidases involved in degradation of the extracellular matrix
(ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene
have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the TIMP3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene belongs to the tissue inhibitor of metalloproteinases
Tissue inhibitor of metalloproteinases
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases , which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4....
gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinase
Matrix metalloproteinase
Matrix metalloproteinases are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily....
s, a group of peptidases involved in degradation of the extracellular matrix
Extracellular matrix
In biology, the extracellular matrix is the extracellular part of animal tissue that usually provides structural support to the animal cells in addition to performing various other important functions. The extracellular matrix is the defining feature of connective tissue in animals.Extracellular...
(ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
External Links
- The MEROPSMeropsMerops may refer to:* Merops , a genus of bee-eaters.* MEROPS, an on-line database for peptidases.It may also refer to several figures from Greek mythology:* King of Ethiopia, husband of Clymene, who lay with Helios and bore Phaethon...
online database for peptidases and their inhibitors: I35.003