TAL2
Encyclopedia
T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein
which in humans is encoded by the TAL2 gene
.
family of transcription factor
s.
(T-ALL).
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the TAL2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
TAL2 is a member of the Basic Helix-Loop-HelixBasic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
family of transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s.
Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemiaT-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia can refer to:* Precursor T acute lymphoblastic leukemia/lymphoma* Adult T-cell leukemia/lymphoma...
(T-ALL).