Stephen Kuffler
Encyclopedia
Stephen William Kuffler was a pre-eminent Hungarian-American neurophysiologist. Often, he's been referred to as the "Father of Modern Neuroscience". He founded the Harvard Neurobiology department in 1966, and made numerous seminal contributions to our understanding of vision
, neural coding
, and the neural implementation of behavior. He is known for his research on neuromuscular junction
s in frogs, presynaptic inhibition
, and the neurotransmitter
GABA
. In 1972, he was awarded the Louisa Gross Horwitz Prize
from Columbia University
.
A detailed, affectionate, and authoritative account of Stephen Kuffler's life and work has been provided by Sir Bernard Katz (Biographical Memoirs of Fellows of the Royal Society, vol. 28, pp. 225-59, 1982) and in a book entitled Steve, Remembrances of Stephen W. Kuffler, compiled and introduced by U. J. McMahan (Sunderland, Mass.: Sinauer Associates, 1990)."
Visual perception
Visual perception is the ability to interpret information and surroundings from the effects of visible light reaching the eye. The resulting perception is also known as eyesight, sight, or vision...
, neural coding
Neural coding
Neural coding is a neuroscience-related field concerned with how sensory and other information is represented in the brain by networks of neurons. The main goal of studying neural coding is to characterize the relationship between the stimulus and the individual or ensemble neuronal responses and...
, and the neural implementation of behavior. He is known for his research on neuromuscular junction
Neuromuscular junction
A neuromuscular junction is the synapse or junction of the axon terminal of a motor neuron with the motor end plate, the highly-excitable region of muscle fiber plasma membrane responsible for initiation of action potentials across the muscle's surface, ultimately causing the muscle to contract...
s in frogs, presynaptic inhibition
Chemical synapse
Chemical synapses are specialized junctions through which neurons signal to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie...
, and the neurotransmitter
Neurotransmitter
Neurotransmitters are endogenous chemicals that transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to...
GABA
Gamma-aminobutyric acid
γ-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system...
. In 1972, he was awarded the Louisa Gross Horwitz Prize
Louisa Gross Horwitz Prize
Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers that have made an outstanding contribution in basic research in the fields of biology or biochemistry....
from Columbia University
Columbia University
Columbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the...
.
Honors and awards
Kuffler was widely recognized as a truly original and creative neuroscientist. In addition to numerous prizes, honorary degrees, and special lectureships from countries over the world, Steve was elected to the National Academy of Sciences in 1964 and to the Royal Society as Foreign Member in 1971. In 1964 he was named the Robert Winthrop professor of neurophysiology and neuropharmacology. From 1966 to 1974 he was the Robert Winthrop professor of neurobiology, and in 1974 he became John Franklin Enders university professor.A detailed, affectionate, and authoritative account of Stephen Kuffler's life and work has been provided by Sir Bernard Katz (Biographical Memoirs of Fellows of the Royal Society, vol. 28, pp. 225-59, 1982) and in a book entitled Steve, Remembrances of Stephen W. Kuffler, compiled and introduced by U. J. McMahan (Sunderland, Mass.: Sinauer Associates, 1990)."
See also
- Eric R. KandelEric R. KandelEric Richard Kandel is an American neuropsychiatrist who was a recipient of the 2000 Nobel Prize in Physiology or Medicine for his research on the physiological basis of memory storage in neurons...
- Torsten WieselTorsten WieselTorsten Nils Wiesel was a Swedish co-recipient with David H. Hubel of the 1981 Nobel Prize in Physiology or Medicine, for their discoveries concerning information processing in the visual system; the prize was shared with Roger W...
- David Hubel
- Seymour BenzerSeymour BenzerSeymour Benzer was an American physicist, molecular biologist and behavioral geneticist. His career began during the molecular biology revolution of the 1950s, and he eventually rose to prominence in the fields of molecular and behavioral genetics. He led a productive genetics research lab both at...
- Gunther StentGunther StentGunther S. Stent was Graduate Professor of Molecular Biology at the University of California, Berkeley. He was born in Berlin as "Günter Siegmund Stensch"; the name was changed after the migration to the USA...
- Louisa Gross Horwitz PrizeLouisa Gross Horwitz PrizeLouisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers that have made an outstanding contribution in basic research in the fields of biology or biochemistry....