Src family kinase is a family of non-receptor tyrosine kinase

Non-receptor tyrosine kinase

Non-receptor tyrosine kinases or non-specific protein-tyrosine kinases are enzymes that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Non-receptor tyrosine kinases are a subgroup of the larger class of tyrosine kinases...

s that includes nine members: Src

Src (gene)

Proto-oncogene tyrosine-protein kinase Src is an enzyme that in humans is encoded by the SRC gene.Src is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. It belongs to a...

, Yes

YES1

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.-Interactions:YES1 has been shown to interact with Janus kinase 2, CTNND1, RPL10 and Occludin.-Further reading:...

, Fyn

FYN

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth...

, and Fgr

FGR (gene)

Gardner-Rasheed feline sarcoma viral oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.- Function :This gene is a member of the Src family of protein tyrosine kinases...

, forming the SrcA subfamily, Lck

Lck

Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes...

, Hck

HCK

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.-Interactions:HCK has been shown to interact with BCR gene, ELMO1, Cbl gene, RAS p21 protein activator 1, RASA3, Granulocyte colony-stimulating factor receptor, ADAM15 and RAPGEF1.-Further reading:...

, Blk, and Lyn in the SrcB subfamily, and Frk

FRK (gene)

Fyn-related kinase is an enzyme that in humans is encoded by the FRK gene.-Interactions:FRK has been shown to interact with retinoblastoma protein.-Further reading:...

 in its own subfamily. Frk has homologs in invertebrate

Invertebrate

An invertebrate is an animal without a backbone. The group includes 97% of all animal species – all animals except those in the chordate subphylum Vertebrata .Invertebrates form a paraphyletic group...

s such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellate

Choanoflagellate

The choanoflagellates are a group of free-living unicellular and colonial flagellate eukaryotes considered to be the closest living relatives of the animals...

s, but the SrcA and SrcB subfamilies are specific to vertebrates.

Src family kinases interact with a variety of cellular cytosolic, nuclear and membrane proteins, modifying these proteins by phosphorylation of tyrosine residues. A number of substrates have been discovered for these enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

s.