Specol
Encyclopedia
Specol is a water in oil adjuvant
composed of defined and purified light mineral oil
(Stills. 2005). It has been suggested as an alternative to Freund's adjuvant
for hyperactivation
of the immune response in rabbit
s (Leenaars et al. 1994). Specol can be used for antigens of low immunogenicity and can be administered equally effectively by the subcutaneous or intraperitoneal routes. The histological lesions produced are fewer than those produced by using Complete Freund's adjuvant
. However, pain and distress
following administration of these 2 adjuvants seem to be similar (based on limited data).
Adjuvant
An adjuvant is a pharmacological or immunological agent that modifies the effect of other agents, such as a drug or vaccine, while having few if any direct effects when given by itself...
composed of defined and purified light mineral oil
Mineral oil
A mineral oil is any of various colorless, odorless, light mixtures of alkanes in the C15 to C40 range from a non-vegetable source, particularly a distillate of petroleum....
(Stills. 2005). It has been suggested as an alternative to Freund's adjuvant
Freund's adjuvant
Freund's adjuvant is a solution of antigen emulsified in mineral oil and used as an immunopotentiator . The complete form, Freund's Complete Adjuvant, is composed of inactivated and dried mycobacteria , whereas the incomplete form lacks the mycobacterial components...
for hyperactivation
Hyperactivation
Hyperactivation is a type of sperm motility. Hyperactivated sperm motility is characterised by a high amplitude, asymmetrical beating pattern of the sperm tail...
of the immune response in rabbit
Rabbit
Rabbits are small mammals in the family Leporidae of the order Lagomorpha, found in several parts of the world...
s (Leenaars et al. 1994). Specol can be used for antigens of low immunogenicity and can be administered equally effectively by the subcutaneous or intraperitoneal routes. The histological lesions produced are fewer than those produced by using Complete Freund's adjuvant
Freund's adjuvant
Freund's adjuvant is a solution of antigen emulsified in mineral oil and used as an immunopotentiator . The complete form, Freund's Complete Adjuvant, is composed of inactivated and dried mycobacteria , whereas the incomplete form lacks the mycobacterial components...
. However, pain and distress
Distress
Distress may refer to:*Distress , occurring when an individual cannot adapt to stress*Suffering*Distress signal, an internationally recognized means for obtaining help...
following administration of these 2 adjuvants seem to be similar (based on limited data).