Sp3 transcription factor, also known as SP3, refers to both a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 and the gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 it is encoded by.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA

DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...

-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

 that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon

Start codon

The start codon is generally defined as the point, sequence, at which a ribosome begins to translate a sequence of RNA into amino acids.When an RNA transcript is "read" from the 5' carbon to the 3' carbon by the ribosome the start codon is the first codon on which the tRNA bound to Met,...

. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.

Interactions

Sp3 transcription factor has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Histone deacetylase 2

Histone deacetylase 2

Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.-Interactions:Histone deacetylase 2 has been shown to interact with CHD3, MTA1, FKBP3, CHD4, RCOR1, Retinoblastoma protein, CDC20, RBBP4, CDH1, EED, GTF2I, Host cell factor C1, PHF21A, BUB3, MXD1, HDAC10, RELA, Sp3...

, PIAS1

PIAS1

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.-Interactions:PIAS1 has been shown to interact with DNMT3A, STAT1, Small ubiquitin-related modifier 1, Sp3 transcription factor, UBE2I and P53.-Further reading:...

, E2F1

E2F1

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.-Interactions:E2F1 has been shown to interact with NCOA6, Retinoblastoma-like protein 1, Retinoblastoma protein, GTF2H1, SKP2, PURA, NPDC1, Sp2 transcription factor, Sp1 transcription factor, CUL1, ARID3A, TOPBP1,...

 and GABPA

GABPA

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.-Interactions:GABPA has been shown to interact with Host cell factor C1, Sp1 transcription factor and Sp3 transcription factor.-External links:...

.

Further reading