E2F1
Encyclopedia
Transcription factor E2F1 is a protein
that in humans is encoded by the E2F1 gene
.
with NCOA6
, Retinoblastoma-like protein 1
, Retinoblastoma protein
, GTF2H1
, SKP2
, PURA
, NPDC1
, Sp2 transcription factor, Sp1 transcription factor, CUL1
, ARID3A
, TOPBP1
, Cyclin A1, TP53BP1
, Cyclin A2
, Sp4 transcription factor, Sp3 transcription factor
, Prohibitin
, NDN
, MDM4
, TFDP1
and Ubiquitin C
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the E2F1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
E2F1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NCOA6
NCOA6
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB-binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...
, Retinoblastoma-like protein 1
Retinoblastoma-like protein 1
Retinoblastoma-like 1 , also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.- Function :The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene...
, Retinoblastoma protein
Retinoblastoma protein
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in the majority types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide...
, GTF2H1
GTF2H1
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.-Interactions:GTF2H1 has been shown to interact with E2F1, XPB, ERCC2, Estrogen receptor alpha, Cyclin-dependent kinase 7 and TCEA1....
, SKP2
SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.- Function :This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box domain...
, PURA
PURA
Transcriptional activator protein Pur-alpha is a protein that in humans is encoded by the PURA gene.-Further reading:...
, NPDC1
NPDC1
Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.-Further reading:...
, Sp2 transcription factor, Sp1 transcription factor, CUL1
CUL1
Cullin 1, also known as CUL1, is a human protein and gene from cullin family.This protein plays an important role in protein degradation and protein ubiquitination....
, ARID3A
ARID3A
AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.-Interactions:ARID3A has been shown to interact with E2F1 and Bruton's tyrosine kinase....
, TOPBP1
TOPBP1
DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.-Interactions:TOPBP1 has been shown to interact with RAD9A, E2F1, Promyelocytic leukemia protein, ZBTB17 and UBR5.-Further reading:...
, Cyclin A1, TP53BP1
TP53BP1
Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.- Clinical significance :53BP1 is underexpressed in most cases of triple-negative breast cancer....
, Cyclin A2
Cyclin A2
Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene.-Interactions:Cyclin A2 has been shown to interact with ITGB3BP, Retinoblastoma-like protein 1, E2F1, CDC6, SKP2 and Flap structure-specific endonuclease 1.-References:...
, Sp4 transcription factor, Sp3 transcription factor
Sp3 transcription factor
Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes...
, Prohibitin
Prohibitin
Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene.The Phb gene has also been described in animals, fungi, plants, and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1...
, NDN
NDN (gene)
Necdin is a protein that in humans is encoded by the NDN gene.-Interactions:NDN has been shown to interact with NUCB2, E2F1, IL1A, Low affinity nerve growth factor receptor, P53 and HNRNPU.-Further reading:...
, MDM4
MDM4
Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.-Interactions:MDM4 has been shown to interact with E2F1, Mdm2 and P53.-Further reading:...
, TFDP1
TFDP1
Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.-Interactions:TFDP1 has been shown to interact with E2F1, E2F5 and P53.-Further reading:...
and Ubiquitin C
Ubiquitin C
Ubiquitin is a protein that in humans is encoded by the UBC gene.-Interactions:Ubiquitin C has been shown to interact with SCNN1A, SCNN1G, Parkin , P70-S6 Kinase 1, TRAF6, HDAC3, SFPQ, S100A10, Mothers against decapentaplegic homolog 3, NOTCH1, HIF1A, Epidermal growth factor receptor, E2F1,...
.