Ski complex
Encyclopedia
The Ski complex is a multi-protein complex
involved in the 3' end degradation of messenger RNA
s. The complex consists of three main protein
s, the RNA helicase
Ski2 and the proteins Ski3 and Ski8. In yeast, the complex guides RNA molecules to the exosome complex
for degradation via a fourth protein, called Ski7, which contains a GTPase
-like protein.
Protein complex
A multiprotein complex is a group of two or more associated polypeptide chains. If the different polypeptide chains contain different protein domain, the resulting multiprotein complex can have multiple catalytic functions...
involved in the 3' end degradation of messenger RNA
Messenger RNA
Messenger RNA is a molecule of RNA encoding a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis: the ribosomes. Here, the nucleic acid polymer is translated into a polymer of amino acids: a protein...
s. The complex consists of three main protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
s, the RNA helicase
Helicase
Helicases are a class of enzymes vital to all living organisms. They are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two annealed nucleic acid strands using energy derived from ATP hydrolysis.-Function:Many cellular processes Helicases are a...
Ski2 and the proteins Ski3 and Ski8. In yeast, the complex guides RNA molecules to the exosome complex
Exosome complex
The exosome complex is a multi-protein complex capable of degrading various types of RNA molecules...
for degradation via a fourth protein, called Ski7, which contains a GTPase
GTPase
GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...
-like protein.