SNX1
Encyclopedia
Sorting nexin-1 is a protein
that in humans is encoded by the SNX1 gene
. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer
complex.
) domain, which is a phosphoinositide
binding domain, and are involved in intracellular trafficking
. This endosomal
protein regulates the cell-surface expression of epidermal growth factor receptor
. This protein also has a role in sorting protease-activated receptor-1
from early endosomes to lysosome
s. This protein may form oligomeric complexes with other family members.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SNX1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer
Retromer
The retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network .-Discovery:...
complex.
Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PXPX domain
The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.This domain was first found in P40phox and p47phox domains of NADPH oxidase...
) domain, which is a phosphoinositide
Phosphatidylinositol
Phosphatidylinositol is a negatively charged phospholipid and a minor component in the cytosolic side of eukaryotic cell membranes....
binding domain, and are involved in intracellular trafficking
Protein targeting
Protein targeting or protein sorting is the mechanism by which a cell transports proteins to the appropriate positions in the cell or outside of it. Sorting targets can be the inner space of an organelle, any of several interior membranes, the cell's outer membrane, or its exterior via secretion...
. This endosomal
Endosome
In biology, an endosome is a membrane-bound compartment inside eukaryotic cells. It is a compartment of the endocytic membrane transport pathway from the plasma membrane to the lysosome. Molecules internalized from the plasma membrane can follow this pathway all the way to lysosomes for...
protein regulates the cell-surface expression of epidermal growth factor receptor
Epidermal growth factor receptor
The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands...
. This protein also has a role in sorting protease-activated receptor-1
Coagulation factor II receptor
Proteinase-activated receptor 1 also known as the coagulation factor II receptor is a protein that in humans is encoded by the F2R gene. PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response...
from early endosomes to lysosome
Lysosome
thumb|350px|Schematic of typical animal cell, showing subcellular components. [[Organelle]]s: [[nucleoli]] [[cell nucleus|nucleus]] [[ribosomes]] [[vesicle |vesicle]] rough [[endoplasmic reticulum]]...
s. This protein may form oligomeric complexes with other family members.