Rs7341475
Encyclopedia
In genetics
, rs7341475 is a single nucleotide polymorphism
(SNP) in the RELN gene that codes the reelin
protein.
The gene is located in the fourth intron
on human chromosome 7.
The gene has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs.
The SNP is currently under investigation for a possible link to schizophrenia
.
A 2008 genome-wide association study
pointed to that a variant of the SNP could elevate the risk for schizophrenia among women.
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....
, rs7341475 is a single nucleotide polymorphism
Single nucleotide polymorphism
A single-nucleotide polymorphism is a DNA sequence variation occurring when a single nucleotide — A, T, C or G — in the genome differs between members of a biological species or paired chromosomes in an individual...
(SNP) in the RELN gene that codes the reelin
Reelin
Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...
protein.
The gene is located in the fourth intron
Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing to generate the final mature RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts. Sequences that are joined together in the final...
on human chromosome 7.
The gene has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs.
The SNP is currently under investigation for a possible link to schizophrenia
Schizophrenia
Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...
.
A 2008 genome-wide association study
Genome-wide association study
In genetic epidemiology, a genome-wide association study , also known as whole genome association study , is an examination of many common genetic variants in different individuals to see if any variant is associated with a trait...
pointed to that a variant of the SNP could elevate the risk for schizophrenia among women.