Rieche formylation
Encyclopedia
Rieche formylation is a type of formylation reaction
. The substrates are sterically hindered aromatic compounds - for example mesitylene
- and the formylation reagent dichloromethyl methyl ether
. The catalyst is titanium tetrachloride
, the workup is acidic. The reaction is named after Alfred Rieche
who invented it in 1960 .
Formylation reaction
A formylation reaction in organic chemistry is the catch-all name for any organic reaction in which an organic compound is functionalized with a formyl group .Aromatic formylation reactions via electrophilic aromatic substitution include:...
. The substrates are sterically hindered aromatic compounds - for example mesitylene
Mesitylene
Mesitylene or 1,3,5-trimethylbenzene is an aromatic hydrocarbon with three methyl substituents attached to the benzene ring. It is prepared by distillation of acetone with sulfuric acid or by trimerization of propyne in sulfuric acid, which, in both cases, acts as a catalyst and dehydrating agent....
- and the formylation reagent dichloromethyl methyl ether
Dichloromethyl methyl ether
Dichloromethyl methyl ether is an organic compound that belongs to the class of ethers with a dichloromethyl group and a methyl group...
. The catalyst is titanium tetrachloride
Titanium tetrachloride
Titanium tetrachloride is the inorganic compound with the formula TiCl4. It is an important intermediate in the production of titanium metal and the pigment titanium dioxide. TiCl4 is an unusual example of a metal halide that is highly volatile...
, the workup is acidic. The reaction is named after Alfred Rieche
Alfred Rieche
-References:...
who invented it in 1960 .