Rickettsia conorii
Encyclopedia
Rickettsia conorii is a unicellular, gram-negative
Gram-negative
Gram-negative bacteria are bacteria that do not retain crystal violet dye in the Gram staining protocol. In a Gram stain test, a counterstain is added after the crystal violet, coloring all Gram-negative bacteria with a red or pink color...

, obligate intracellular
Obligate intracellular parasite
Intracellular parasites are parasitic microorganisms - microparasites that are capable of growing and reproducing inside the cells of a host.-Facultative:...

 bacterium of the genus Rickettsia
Rickettsia
Rickettsia is a genus of non-motile, Gram-negative, non-sporeforming, highly pleomorphic bacteria that can present as cocci , rods or thread-like . Being obligate intracellular parasites, the Rickettsia survival depends on entry, growth, and replication within the cytoplasm of eukaryotic host cells...

that causes human disease called Boutonneuse fever
Boutonneuse fever
Boutonneuse fever is a fever as a result of a Rickettsia infection caused by the bacterium Rickettsia conorii and transmitted by the dog tick Rhipicephalus sanguineus...

, Mediterranean spotted fever, Israeli tick typhus, Astrakhan spotted fever, Kenya tick typhus, Indian tick typhus, or other names that designate the locality of occurrence while having distinct clinical features. It is a member of the spotted fever
Spotted fever
A spotted fever is a type of tick-borne disease which presents on the skin.Types include:* Mediterranean spotted fever* Rocky Mountain spotted fever* Queensland tick typhus...

 group and the most geographically dispersed species in the group, recognized in most of the regions bordering on the Mediterranean Sea
Mediterranean Sea
The Mediterranean Sea is a sea connected to the Atlantic Ocean surrounded by the Mediterranean region and almost completely enclosed by land: on the north by Anatolia and Europe, on the south by North Africa, and on the east by the Levant...

 and Black Sea
Black Sea
The Black Sea is bounded by Europe, Anatolia and the Caucasus and is ultimately connected to the Atlantic Ocean via the Mediterranean and the Aegean seas and various straits. The Bosphorus strait connects it to the Sea of Marmara, and the strait of the Dardanelles connects that sea to the Aegean...

, Israel
Israel
The State of Israel is a parliamentary republic located in the Middle East, along the eastern shore of the Mediterranean Sea...

, Kenya
Kenya
Kenya , officially known as the Republic of Kenya, is a country in East Africa that lies on the equator, with the Indian Ocean to its south-east...

 and other parts of North
North Africa
North Africa or Northern Africa is the northernmost region of the African continent, linked by the Sahara to Sub-Saharan Africa. Geopolitically, the United Nations definition of Northern Africa includes eight countries or territories; Algeria, Egypt, Libya, Morocco, South Sudan, Sudan, Tunisia, and...

, Central
Central Africa
Central Africa is a core region of the African continent which includes Burundi, the Central African Republic, Chad, the Democratic Republic of the Congo, and Rwanda....

, and South Africa
Southern Africa
Southern Africa is the southernmost region of the African continent, variably defined by geography or geopolitics. Within the region are numerous territories, including the Republic of South Africa ; nowadays, the simpler term South Africa is generally reserved for the country in English.-UN...

, and India
India
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...

. The prevailing vector is the brown dog tick, Rhipicephalus sanguineus
Rhipicephalus sanguineus
The brown dog tick, Rhipicephalus sanguineus, is a species of tick which is found world-wide, but more commonly in warmer climates. This species is unusual among ticks in that its entire life cycle can be completed indoors.-Hosts:...

. The bacterium was isolated by Emile Brumpt
Emile Brumpt
Alexandre Joseph Emile Brumpt was a French parasitologist who was born in Paris. He studied zoology and parasitology in Paris, obtaining his degree in science in 1901, and his medical doctorate in 1906. In 1919 he became a professor to the Faculté de Médecine, as well as director of the...

 in 1932 and named after A. Conor who, in collaboration with A. Bruch, provided the first description of boutonneuse fever in Tunisia
Tunisia
Tunisia , officially the Tunisian RepublicThe long name of Tunisia in other languages used in the country is: , is the northernmost country in Africa. It is a Maghreb country and is bordered by Algeria to the west, Libya to the southeast, and the Mediterranean Sea to the north and east. Its area...

in 1910.

The genome of the bacterium has been sequenced and four subspecies have been identified.
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