RhoGAP domain is an evolutionary conserved protein domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

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GTPase activating protein

GTPase activating protein

GTPase-Activating Proteins, or GAPs, or GTPase-Accelerating Proteins are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event...

s towards Rho

Rho

Rho is the 17th letter of the Greek alphabet. In the system of Greek numerals, it has a value of 100. It is derived from Semitic resh "head"...

/Rac

RAC

-Companies:* Rent-A-Center, an American public furniture and electronics rent to own company* Royal Automobile Club, a private club in Pall Mall, London* RAC plc, a breakdown company in the United Kingdom...

/Cdc42

CDC42

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...

-like small GTPase

GTPase

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...

s.

Human proteins containing this domain

ABR; ARHGAP1

ARHGAP1

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.-Interactions:ARHGAP1 has been shown to interact with CDC42, BNIP2 and RHOA.-Further reading:...

; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17;
ARHGAP18; ARHGAP19

ARHGAP19

Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ARHGAP19 gene.-Further reading:...

; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24

ARHGAP24

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene.-Further reading:...

; ARHGAP25;
ARHGAP26

ARHGAP26

Rho GTPase activating protein 26 also known as GTPase Regulator Associated with Focal Adhesion Kinase is a protein which in humans is encoded by the ARHGAP26 gene.-Function:...

; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4

ARHGAP4

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell motility and axonal outgrowth in vitro.-Further reading:...

; ARHGAP5

ARHGAP5

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.-Interactions:ARHGAP5 has been shown to interact with Rnd1, Rnd2, Rnd3 and RHOA.-Further reading:...

; ARHGAP6;
ARHGAP8

ARHGAP8

Rho GTPase-activating protein 8 is an enzyme that in humans is encoded by the ARHGAP8 gene.-Further reading:...

; ARHGAP9

ARHGAP9

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.-Further reading:...

; BCR

BCR gene

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.-Pathology:...

; BPGAP1; C1

C1

- Diverse :* C1, an international standard paper size defined in ISO 216 * Bills C-1 and S-1, a pro forma bill normally introduced at the start of a parliamentary session in the Canadian House of Commons...

; C5orf5; CDGAP; CENTD1

CENTD1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.-Further reading:...

;
CENTD2

CENTD2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.-Further reading:...

; CENTD3

CENTD3

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.-Further reading:...

; CHN1; CHN2

CHN2

Beta-chimaerin is a protein that in humans is encoded by the CHN2 gene.-Further reading:...

; DEPDC1; DEPDC1A; DEPDC1B; DLC1

DLC1

Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 is a protein which in humans is encoded by the DLC1 gene....

;
FAM13A1

FAM13A1

Protein FAM13A is a protein that in humans is encoded by the FAM13A gene.-Further reading:...

; FKSG42; GMIP; GRLF1

GRLF1

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.- External links :* Info with links in the...

; HMHA1

HMHA1

Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene.-Further reading:...

; INPP5B

INPP5B

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.-Further reading:...

; KIAA1688; LOC553158;
MYO9A; MYO9B

MYO9B

Myosin-IXb is a protein that in humans is encoded by the MYO9B gene.-Further reading:...

; OCRL

OCRL

Inositol polyphosphate 5-phosphatase OCRL-1 also known as Lowe oculocerebrorenal syndrome protein is an enzyme that in humans is encoded by the OCRL gene located on the X chromosome....

; OPHN1

OPHN1

Oligophrenin-1 is a protein that in humans is encoded by the OPHN1 gene.-Further reading:...

; PIK3R1

PIK3R1

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.-Interactions:PIK3R1 has been shown to interact with EPH receptor A2, KHDRBS1, Lymphocyte cytosolic protein 2, Janus kinase 2, GAB2, CD117, BCAR1, CD28, SHB, EZR, PIK3CD, GAB1, HRAS,...

; PIK3R2

PIK3R2

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.-Interactions:PIK3R2 has been shown to interact with FYN, HER2/neu, Epidermal growth factor, Cbl gene, PIK3CD, CRKL and Macrophage colony-stimulating factor.-Further reading:...

; PRR5; RACGAP1

RACGAP1

Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.-Interactions:RACGAP1 has been shown to interact with Rnd2 and SLC26A8.-Further reading:...

;
RACGAP1P; RALBP1

RALBP1

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.-Interactions:RALBP1 has been shown to interact with RALA, REPS2, Cyclin B1, RALB and HSF1.-Further reading:...

; RICH2; RICS; SH3BP1

SH3BP1

SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene.-Further reading:...

; SLIT1

SLIT1

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.-Further reading:...

; SNX26

SNX26

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.-Further reading:...

; SRGAP1

SRGAP1

SLIT-ROBO Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the SRGAP1 gene.-Further reading:...

;
SRGAP2

SRGAP2

SRGAP2 is a gene involved in neuronal migration. A shortened version of this protein allows neurons to migrate faster.This gene is one of the 23 genes that is duplicated in humans but not in other primates....

; SRGAP3

SRGAP3

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.-Further reading:...

; STARD13

STARD13

StAR-related lipid transfer domain protein 13 also known as deleted in liver cancer 2 protein is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.-Function and structure:...

; STARD8

STARD8

StAR-related lipid transfer domain protein 8 also known as deleted in liver cancer 3 protein is a protein that in humans is encoded by the STARD8 gene and is a member of the DLC family.-Structure and function:...

; SYDE1; SYDE2;