RasGEF domain is domain found in a family

Protein family

A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....

 of guanine nucleotide exchange factor

Guanine nucleotide exchange factor

Guanine nucleotide exchange factors activate monomeric GTPases by stimulating the release of guanosine diphosphate to allow binding of guanosine triphosphate . A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity...

s for Ras

Ras superfamily

The Ras superfamily is a protein superfamily of small GTPases, which are all related, to a degree, to the Ras protein subfamily .There are more than a hundred proteins in the Ras superfamily...

-like small GTPase

GTPase

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...

s.
Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)). Proteins that act as GDS can be classified into at least two families, on the basis of sequence similarities, the CDC24 family (see ) and this CDC25 (RasGEF) family.

The size of the proteins of the CDC25 family range from 309 residues (LTE1) to 1596 residues (sos). The sequence similarity shared by all these proteins is limited to a region of about 250 amino acids generally located in their C-terminal section (currently the only exceptions are sos and ralGDS where this domain makes up the central part of the protein). This domain has been shown, in CDC25 an SCD25, to be essential for the activity of these proteins.

Human proteins containing this domain

KNDC1; PLCE1

PLCE1

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an enzyme that in humans is encoded by the PLCE1 gene.- Function :...

; RALGDS

RALGDS

Ral guanine nucleotide dissociation stimulator is a protein that in humans is encoded by the RALGDS gene.-Interactions:RALGDS has been shown to interact with RRAS, RAP2A, RAP1A, KRAS, RAPGEF2, MRAS, HRAS, Arrestin beta 2 and Arrestin beta 1....

; RALGPS1; RALGPS2; RAPGEF1

RAPGEF1

Rap guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the RAPGEF1 gene.-Interactions:RAPGEF1 has been shown to interact with BCAR1, Grb2, HCK, CRKL and CRK.-External links:* Info with links in the...

; RAPGEF2

RAPGEF2

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.-Interactions:RAPGEF2 has been shown to interact with RAP1A and RALGDS.-Further reading:...

; RAPGEF3

RAPGEF3

Rap guanine nucleotide exchange factor 3 is a protein that in humans is encoded by the RAPGEF3 gene.-Further reading:...

;
RAPGEF4

RAPGEF4

Rap guanine nucleotide exchange factor 4 , also known as exchange protein directly activated by cAMP 2 , is a protein which in humans is encoded by the RAPGEF4 gene.-Further reading:...

; RAPGEF5

RAPGEF5

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.-Further reading:...

; RAPGEF6

RAPGEF6

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.-Further reading:...

; RAPGEFL1; RASGEF1A; RASGEF1B; RASGEF1C; RASGRF1;
RASGRP; RASGRP1

RASGRP1

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.- Function :RAS guanyl nucleotide-releasing protein is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor domain...

; RASGRP2

RASGRP2

RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.-Further reading:...

; RASGRP3

RASGRP3

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.-Further reading:...

; RASGRP4; RGL1; RGL2

RGL2

Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.-Further reading:...

; RGL3;
RGR; Rgr

RGR

RGR can refer to:* Royal Gurkha Rifles* RGR...

; SOS1

SOS1

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.Recent studies also show that mutations in Sos1 can cause Noonan syndrome and hereditary gingival fibromatosis type 1. Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes...

; SOS2;

Further reading

• Proteins regulating Ras and its relatives. Boguski MS, McCormick F; Nature 1993;366:643-654.
• Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Quilliam LA, Khosravi-Far R, Huff SY, Der CJ; Bioessays 1995;17:395-404.
• Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J; Nature 1993;363:85-88.
• The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J; Science 1993;260:1953-1955.