Pyogenic liver abscess
Encyclopedia
A pyogenic liver abscess is a type of liver abscess
Liver abscess
A liver abscess is a pus-filled mass inside the liver. Common causes are abdominal infections such as appendicitis or diverticulitis due to haematogenous spread through the portal vein...

 caused by bacteria.

Etiology

  • Biliary disease{most common}
  • Colonic disease
  • Cryptogenic disease
    Cryptogenic disease
    A cryptogenic disease is a disease of which the cause is unknown. It may be used in a particular case, when the nature of the patient's condition is known but the cause has not been found . The word cryptogenic also appears in the names of some disease entities, when the situation is sufficiently...

  • Pancreatitis
  • Infection of blood
  • Abdominal infection
  • Infection of biliary system
  • Trauma of liver

Common bacterial causes

  • Streptococcus milleri
  • E. coli
  • Streptococcus fecalis
  • Klebsiella pneumoniae
    Klebsiella pneumoniae
    Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose fermenting, facultative anaerobic, rod shaped bacterium found in the normal flora of the mouth, skin, and intestines....

  • Proteus vulgaris
    Proteus vulgaris
    Proteus vulgaris is a rod-shaped, Gram negative bacterium that inhabits the intestinal tracts of humans and animals. It can be found in soil, water and fecal matter. It is grouped with the enterobacteriaceae and is an opportunistic pathogen of humans...

  • Bacteroides
    Bacteroides
    Bacteroides is a genus of Gram-negative, bacillus bacteria. Bacteroides species are non-endospore-forming, anaerobes, and may be either motile or non-motile, depending on the species. The DNA base composition is 40-48% GC. Unusual in bacterial organisms, Bacteroides membranes contain sphingolipids...

  • Opportunistic Pathogens (Staphylococcus
    Staphylococcus
    Staphylococcus is a genus of Gram-positive bacteria. Under the microscope they appear round , and form in grape-like clusters....

    )

Clinical features

  • 1.Acute Abscess
  • Fever
    Fever
    Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...

  • Lethargy
  • Discomfort in Right Upper Quadrant Of Abdomen
  • Anorexia
    Anorexia (symptom)
    Anorexia is the decreased sensation of appetite...

  • Enlarged and Tender Liver
  • Pleural effusion
    Pleural effusion
    Pleural effusion is excess fluid that accumulates between the two pleural layers, the fluid-filled space that surrounds the lungs. Excessive amounts of such fluid can impair breathing by limiting the expansion of the lungs during ventilation.-Pathophysiology:...


  • 2.Chronic Abscess
  • Fever
  • Abdominal discomfort
  • Enlarged Liver

Diagnosis

  • Blood CP (No Leucocytosis)
  • Haemoglobin estimation (anaemia)
  • Serum albumin
    Serum albumin
    Serum albumin, often referred to simply as albumin is a protein that in humans is encoded by the ALB gene.Serum albumin is the most abundant plasma protein in mammals. Albumin is essential for maintaining the osmotic pressure needed for proper distribution of body fluids between intravascular...

     levels (Falls rapidly)
  • USG and CT Scanning

Treatment

  • 1.Antibiotics

* Penicillin
Penicillin
Penicillin is a group of antibiotics derived from Penicillium fungi. They include penicillin G, procaine penicillin, benzathine penicillin, and penicillin V....

s
* Aminoglycoside
Aminoglycoside
An aminoglycoside is a molecule or a portion of a molecule composed of amino-modifiedsugars.Several aminoglycosides function as antibiotics that are effective against certain types of bacteria...

s
* Metronidazole
Metronidazole
Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal....


* Cephalosporin
Cephalosporin
The cephalosporins are a class of β-lactam antibiotics originally derived from Acremonium, which was previously known as "Cephalosporium".Together with cephamycins they constitute a subgroup of β-lactam antibiotics called cephems.-Medical use:...

s
  • 2.Percutaneous Drainage under USG or CT Control
  • 3.Laparotomy
    Laparotomy
    A laparotomy is a surgical procedure involving a large incision through the abdominal wall to gain access into the abdominal cavity. It is also known as coeliotomy.- Terminology :...

    in intraabdominal disease
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