Phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.

Human proteins containing this domain

EPS8

EPS8

Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the EPS8 gene.-Interactions:EPS8 has been shown to interact with BAIAP2, SHB, Src, SOS1, DVL1, SHC1 and ABI1.-Further reading:...

; EPS8L1

EPS8L1

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.-Further reading:...

; EPS8L2

EPS8L2

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.-Further reading:...

; EPS8L3

EPS8L3

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.-Further reading:...

; TENC1

TENC1

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.-Interactions:TENC1 has been shown to interact with AXL receptor tyrosine kinase.-Further reading:...

; TNS

TNS

TNS can stand for:* Taylor Nelson Sofres, a market research company* Tao Nan School, a primary school in Singapore* Taran Noah Smith, an American actor* Temporal noise shaping, an audio encoding technique* The Natural Step, a sustainability framework...

; TNS1

TNS1

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.-External links:* Info with links in the -Further reading:...

; TNS3;
TNS4

TNS4

Tensin-4 is a protein that in humans is encoded by the TNS4 gene.-Further reading:...

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