Phosphoribosyl pyrophosphate - AbsoluteAstronomy.com

Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate

Sugar phosphates

Sugar phosphates are often used in biological systems to store or transfer energy. They also form the backbone for DNA and RNA ....

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It is formed from ribose 5-phosphate

Ribose 5-phosphate

Ribose 5-phosphate is both a product and an intermediate of the pentose phosphate pathway. The last step of the oxidative reactions in the pentose phosphate pathway is the production of ribulose-5-phosphate. Depending on the body's state, ribulose-5-phosphate can reversibly isomerize to...

by the enzyme ribose-phosphate diphosphokinase

Ribose-phosphate diphosphokinase

Ribose-phosphate diphosphokinase is an enzyme that converts ribose 5-phosphate into phosphoribosyl pyrophosphate.It is classified under .-External Links:* * * * *...

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It plays a role in transferring phospho-ribose groups in several reactions:

Enzyme	Reactant	>\|- \| adenine phosphoribosyltransferase Adenine phosphoribosyltransferase Adenine phosphoribosyltransferase is an enzyme that in humans is encoded by the APRT gene.- Function :APRTase is an enzyme involved in the purine nucleotide salvage pathway...	adenine Adenine Adenine is a nucleobase with a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate and the cofactors nicotinamide adenine dinucleotide and flavin adenine dinucleotide , and protein synthesis, as a chemical component of DNA...	AMP Adenosine monophosphate Adenosine monophosphate , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine... >- \| hypoxanthine-guanine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase is an enzyme encoded in humans by the HPRT1 gene.HGPRT is a transferase that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. This reaction transfers the 5-phosphoribosyl group from...	guanine Guanine Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine . In DNA, guanine is paired with cytosine. With the formula C5H5N5O, guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with...	GMP Guanosine monophosphate Guanosine monophosphate, also known as 5'-guanidylic acid or guanylic acid and abbreviated GMP, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside guanosine. GMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase... >- \| hypoxanthine-guanine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase is an enzyme encoded in humans by the HPRT1 gene.HGPRT is a transferase that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. This reaction transfers the 5-phosphoribosyl group from...	hypoxanthine Hypoxanthine Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-Hydroxypurine. Hypoxanthine is a necessary additive in certain cell,...	>- \| orotate phosphoribosyltransferase Orotate phosphoribosyltransferase Orotate phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the formation of orotidine 5'-monophosphate from orotate and phosphoribosyl pyrophosphate...	orotate	OMP Orotidine 5'-monophosphate Orotidine 5'-monophosphate , also known as orotidylic acid, is a pyrimidine nucleotide which is the last intermediate in the biosynthesis of uridine monophosphate. OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme Orotate phosphoribosyltransferaseIn humans, the enzyme UMP... >- \| uracil phosphoribosyltransferase Uracil phosphoribosyltransferase Uracil phosphoribosyltransferase is an enzyme which creates UMP from uracil and phosphoribosylpyrophosphate....	uracil Uracil Uracil is one of the four nucleobases in the nucleic acid of RNA that are represented by the letters A, G, C and U. The others are adenine, cytosine, and guanine. In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine.Uracil is a common and...	UMP Uridine monophosphate Uridine monophosphate, also known as 5'-uridylic acid and abbreviated UMP, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside uridine...

In de novo
De novo synthesis
De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to their being recycled after partial degradation. For example, nucleotides are not needed in the diet as they can be constructed from small precursor molecules such as...

generation of purines, the enzyme amidophosphoribosyltransferase

Amidophosphoribosyltransferase

Amidophosphoribosyltransferase , also known as glutamine phosphoribosylpyrophosphate amidotransferase , is an enzyme that in humans is encoded by the PPAT gene.- Function :...

acts upon PRPP to create phosphoribosylamine

Phosphoribosylamine

Phosphoribosylamine is an intermediate in purine metabolism. It is a precursor to IMP. It is generated from Phosphoribosyl pyrophosphate .-See also:* Amidophosphoribosyltransferase* Phosphoribosyl pyrophosphate...