Phospholipase D1
Encyclopedia
Phospholipase D1 is an enzyme
that in humans is encoded by the PLD1 gene
.
with RALA
, BIN1
, Amphiphysin
, Alpha-synuclein
, PEA15
, RHOA
, Protein kinase N1
and CDC42
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the PLD1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
Phospholipase D1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with RALA
RALA
Ras-related protein Ral-A is a protein that in humans is encoded by the RALA gene.-Interactions:RALA has been shown to interact with Filamin, Phospholipase D1 and RALBP1.-Further reading:...
, BIN1
BIN1
Myc box-dependent-interacting protein 1 is a protein that in humans is encoded by the BIN1 gene.-Interactions:BIN1 has been shown to interact with Phospholipase D1, SNX4 and PLD2.-Further reading:...
, Amphiphysin
Amphiphysin
Amphiphysin is a protein that in humans is encoded by the AMPH gene.Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain...
, Alpha-synuclein
Alpha-synuclein
Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. An alpha-synuclein fragment, known as the non-Abeta component of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, is shown to be a fragment of its precursor protein, NACP, by cloning of the...
, PEA15
PEA15
Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.PEA15 is a death effector domain -containing protein predominantly expressed in the central nervous system, particularly in astrocytes....
, RHOA
RHOA
Ras homolog gene family, member A is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. In humans, it is encoded by the gene RHOA....
, Protein kinase N1
Protein kinase N1
Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.-Interactions:Protein kinase N1 has been shown to interact with Phospholipase D1, Phosphoinositide-dependent kinase-1, Vimentin, AKAP9, CCDC85B, Actinin, alpha 1, NEFL, NEUROD2 and RHOA.-Further reading:...
and CDC42
CDC42
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...
.
Inhibitors
- VU-0359595: 1,700-fold selective versus phospholipase D2PLD2Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.-Interactions:PLD2 has been shown to interact with BIN1, Amphiphysin, Aldolase A, PLCG1, ARF1, Src, PRKCD, Glyceraldehyde 3-phosphate dehydrogenase ,Caveolin 1,and Wiskott-Aldrich syndrome protein.-Inhibitors:* N--2-naphthamide:...
, IC50 = 3.7nM.