Phenylpiperidine
Encyclopedia
Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine
. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system
effects.
"Phenyl"piperidines >
Compound
N
4-position
3-position
4'-position
Type of Pharmacology
MPPP
Me
Ph
H
opioid analgesic
Prodine
Me
Ph
Me
opioid analgesic
PEPAP
CH2CH2Ph
Ph
H
opioid analgesic
Pethidine
Me
Ph
H
2Et>
mu-agonist with SRI properties
Budipine
t-Bu
Ph
H
Ph
antiparkinson agent
Ketobemidone
Me
3-HO-Ph
H
opioid + NMDA antagonist
Paroxetine
H
4-F-Ph
2OAr>
H
SSRI (+ NET)
Femoxetine
Me
Ph
2O(4-MeOPh)>
H
(S)SRI
CPCA
Me
4-Cl-Ph
2Me>
H
monoamine reuptake inhibitor
Ar = benzodioxol-3-yl
Methylphenidate
is a benzyl
piperidine.
Piperidine
Piperidine is an organic compound with the molecular formula 5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom...
. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system
Central nervous system
The central nervous system is the part of the nervous system that integrates the information that it receives from, and coordinates the activity of, all parts of the bodies of bilaterian animals—that is, all multicellular animals except sponges and radially symmetric animals such as jellyfish...
effects.
MPPP
1-Methyl-4-phenyl-4-propionoxypiperidine or Desmethylprodine is an opioid analgesic drug developed in the 1940s by researchers at Hoffmann-La Roche. It is not used in clinical practice, but has been illegally manufactured for recreational drug use...
Prodine
Prodine is an opioid analgesic that is an analogue of pethidine .There are two isomers of prodine, Alphaprodine and Betaprodine. Betaprodine is some 5x more potent than alphaprodine, but is metabolised more rapidly, and only alphaprodine was developed for medicinal use...
PEPAP
PEPAP is an opioid analgesic that is an analog of pethidine .It is related to the drug MPPP, with an N-phenethyl group in place of the N-methyl substitution and an acetate ester rather than propionate. PEPAP is approximately 6-7 times more potent than morphine in laboratory rats...
Pethidine
Pethidine or meperidine Pethidine (INN) or meperidine (USAN) Pethidine (INN) or meperidine (USAN) (commonly referred to as Demerol but also referred to as: isonipecaine; lidol; pethanol; piridosal; Algil; Alodan; Centralgin; Dispadol; Dolantin; Mialgin (in Indonesia); Petidin Dolargan (in Poland);...
Budipine
Budipine is an antiparkinson agent.Its mechanism of action is not well characterized. It is believed to be an NMDA receptor antagonist, however, promoting the synthesis of dopamine....
Ketobemidone
Ketobemidone is a powerful opioid analgesic. Its effectiveness against pain is in the same range as morphine, and it also has some NMDA-antagonist properties imparted by it's metabolite norketobemidone. This makes it useful for some types of pain that don't respond well to other opioids...
Paroxetine
Paroxetine is an SSRI antidepressant. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, now GlaxoSmithKline...
Femoxetine
Femoxetine is a drug related to paroxetine that was being developed as an antidepressant by the pharmaceutical company Ferrosan in 1974. It functions as a selective serotonin reuptake inhibitor . Development was halted for unknown reasons, perhaps to focus attention on paroxetine instead.Dr...
Reuptake inhibitor
A reuptake inhibitor , also known as a transporter blocker, is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an...
Ar = benzodioxol-3-yl
Methylphenidate
Methylphenidate
Methylphenidate is a psychostimulant drug approved for treatment of attention-deficit hyperactivity disorder, postural orthostatic tachycardia syndrome and narcolepsy. It may also be prescribed for off-label use in treatment-resistant cases of lethargy, depression, neural insult and obesity...
is a benzyl
Benzyl
In organic chemistry, benzyl is the term used to describe the substituent or molecular fragment possessing the structure C6H5CH2-. Benzyl features a benzene ring attached to a CH2 group.-Nomenclature:...
piperidine.