Pharmacological gene therapy
Encyclopedia
Pharmacological gene therapy is a new field that combines pharmacological therapy
and gene therapy
. It is used either to prevent a defective gene from producing its protein or to increase the concentration of normal protein produced in the body by insertion of DNA or RNA fragments. It can also be using to generate immunity from contagious disease, such as TB, via the process of DNA vaccination.
Gene Therapeutics can be used to treat such conditions as Cystic Fibrosis
(via the addition of a normal CFTR gene), Haemophilia A
or even some of the complications of AIDS
.
It uses a number of methods including:
Gene
augmentation
Targeted Inhibition (using Antisense or antigene technology)
Cell Killing (either direct or assisted)
and DNA vaccination
.
Pharmacology
Pharmacology is the branch of medicine and biology concerned with the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function...
and gene therapy
Gene therapy
Gene therapy is the insertion, alteration, or removal of genes within an individual's cells and biological tissues to treat disease. It is a technique for correcting defective genes that are responsible for disease development...
. It is used either to prevent a defective gene from producing its protein or to increase the concentration of normal protein produced in the body by insertion of DNA or RNA fragments. It can also be using to generate immunity from contagious disease, such as TB, via the process of DNA vaccination.
Gene Therapeutics can be used to treat such conditions as Cystic Fibrosis
Cystic fibrosis
Cystic fibrosis is a recessive genetic disease affecting most critically the lungs, and also the pancreas, liver, and intestine...
(via the addition of a normal CFTR gene), Haemophilia A
Haemophilia A
Haemophilia A is a deficiency in clotting factor VIII.Haemophilia A is inherited as an X-linked recessive trait, and thus occurs in males and in homozygous females. However, mild haemophilia A has been described in heterozygous females, presumably due to extremely unfavourable lyonization...
or even some of the complications of AIDS
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...
.
It uses a number of methods including:
Gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
augmentation
Targeted Inhibition (using Antisense or antigene technology)
Cell Killing (either direct or assisted)
and DNA vaccination
Vaccination
Vaccination is the administration of antigenic material to stimulate the immune system of an individual to develop adaptive immunity to a disease. Vaccines can prevent or ameliorate the effects of infection by many pathogens...
.