Paul Lewi
Encyclopedia
Paul J. Lewi is a Belgian
scientist, who elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics
in 1983. Paul Lewi is married with Philomena Van Bylen, and together they have 5 children.
, Belgium
. His parents, Leo Lewi and Mariette Devocht, were professional artist
s and teacher
s. He graduated as Industrial Engineer
in Nuclear Chemistry at the Hoger Rijksinstituut voor Technisch Onderwijs en Kernenergiebedrijven Mol, in 1960 and as a Candidate in Mathematical Sciences at the Catholic University of Leuven
in 1962. He obtained a PhD in Pharmaceutical Sciences at the Vrije Universiteit Brussel
in 1995.
He started working at Janssen Pharmaceutica
in 1962, first as mathematical analyst in Cardiovascular Research, then he became the head of Applied Mathematics in 1967, and head of the Scientific Computer department in 1969. He became head of the Information Science department (1973) and finally vice-president of the Center for Molecular Design (CMD) in 1995, which he founded together with Paul Janssen
. During his career he elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics
in 1983. He is named as co-inventor of a novel series of anti-HIV compounds (Diarylpyrimidines
) including dapivirine, etravirine
and rilpivirine
. After his retirement he serves as visiting professor at the Universities of Leuven, Antwerp and Brussels.
Articles, a selection:
Belgium
Belgium , officially the Kingdom of Belgium, is a federal state in Western Europe. It is a founding member of the European Union and hosts the EU's headquarters, and those of several other major international organisations such as NATO.Belgium is also a member of, or affiliated to, many...
scientist, who elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics
Chemometrics
Chemometrics is the science of extracting information from chemical systems by data-driven means. It is a highly interfacial discipline, using methods frequently employed in core data-analytic disciplines such as multivariate statistics, applied mathematics, and computer science, in order to...
in 1983. Paul Lewi is married with Philomena Van Bylen, and together they have 5 children.
Biography
Paul Lewi was born in 1938 in WestmalleWestmalle
Westmalle is a village which is located in the Belgian province of Antwerp. The village itself is part of the municipality of Malle.-Tourism:...
, Belgium
Belgium
Belgium , officially the Kingdom of Belgium, is a federal state in Western Europe. It is a founding member of the European Union and hosts the EU's headquarters, and those of several other major international organisations such as NATO.Belgium is also a member of, or affiliated to, many...
. His parents, Leo Lewi and Mariette Devocht, were professional artist
Artist
An artist is a person engaged in one or more of any of a broad spectrum of activities related to creating art, practicing the arts and/or demonstrating an art. The common usage in both everyday speech and academic discourse is a practitioner in the visual arts only...
s and teacher
Teacher
A teacher or schoolteacher is a person who provides education for pupils and students . The role of teacher is often formal and ongoing, carried out at a school or other place of formal education. In many countries, a person who wishes to become a teacher must first obtain specified professional...
s. He graduated as Industrial Engineer
Engineer
An engineer is a professional practitioner of engineering, concerned with applying scientific knowledge, mathematics and ingenuity to develop solutions for technical problems. Engineers design materials, structures, machines and systems while considering the limitations imposed by practicality,...
in Nuclear Chemistry at the Hoger Rijksinstituut voor Technisch Onderwijs en Kernenergiebedrijven Mol, in 1960 and as a Candidate in Mathematical Sciences at the Catholic University of Leuven
Catholic University of Leuven
The Catholic University of Leuven, or of Louvain, was the largest, oldest and most prominent university in Belgium. The university was founded in 1425 as the University of Leuven by John IV, Duke of Brabant and approved by a Papal bull by Pope Martin V.During France's occupation of Belgium in the...
in 1962. He obtained a PhD in Pharmaceutical Sciences at the Vrije Universiteit Brussel
Vrije Universiteit Brussel
The Vrije Universiteit Brussel is a Flemish university located in Brussels, Belgium. It has two campuses referred to as Etterbeek and Jette.The university's name is sometimes abbreviated by "VUB" or translated to "Free University of Brussels"...
in 1995.
He started working at Janssen Pharmaceutica
Janssen Pharmaceutica
Janssen Pharmaceutica is pharmaceutical company, established in Belgium in 1953 by Paul Janssen. Its headquarters are located in Beerse, in the Campine region of the province of Antwerp, Belgium. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting...
in 1962, first as mathematical analyst in Cardiovascular Research, then he became the head of Applied Mathematics in 1967, and head of the Scientific Computer department in 1969. He became head of the Information Science department (1973) and finally vice-president of the Center for Molecular Design (CMD) in 1995, which he founded together with Paul Janssen
Paul Janssen
Paul Adriaan Jan, Baron Janssen was the founder of Janssen Pharmaceutica, a pharmaceutical company with over 20,000 employees. In 2005 he finished as runner up, after Father Damien, in the poll for The Greatest Belgian organized by the regional Flemish television...
. During his career he elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics
Chemometrics
Chemometrics is the science of extracting information from chemical systems by data-driven means. It is a highly interfacial discipline, using methods frequently employed in core data-analytic disciplines such as multivariate statistics, applied mathematics, and computer science, in order to...
in 1983. He is named as co-inventor of a novel series of anti-HIV compounds (Diarylpyrimidines
Diarylpyrimidines
Diarylpyrimidines and diaryltriazines are two closely related classes of molecules resembling the pyrimidine nucleotides found in DNA. They show great potency in inhibiting the activity of HIV reverse transcriptase...
) including dapivirine, etravirine
Etravirine
Etravirine is a drug used for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase inhibitor . Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. Etravirine is marketed by Tibotec, a subsidiary...
and rilpivirine
Rilpivirine
Rilpivirine is a pharmaceutical drug, developed by Tibotec, for the treatment of HIV infection. It is a second-generation non-nucleoside reverse transcriptase inhibitor with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.Rilpivirine...
. After his retirement he serves as visiting professor at the Universities of Leuven, Antwerp and Brussels.
Publications
Books:- Lewi P.J. (1982). Multivariate data analysis in industrial practice. Research Studies Press, John Wiley & Sons, Chichester etc., 1982, ISBN0471104663.
- Lewi P.J. (1995). Spectral mapping of drug-test specificities with extensions to the classification of receptor proteins and the correlation of activity spectra. Vrije Universiteit Brussel, Brussel, 1995, proefschrift faculteit geneeskunde en farmacie.
- D.L. Massart, B. Vandeginste, L. Buydens, S. De Jong, P. Lewi and J. Smeyers-Verbeke, Handbook of Chemometrics and Qualimetrics. Vol 20 A, (1997), Elsevier.
- B. Vandeginste, D.L. Massart, L. Buydens, S. De Jong, P. Lewi and J. Smeyers-Verbeke, Handbook of Chemometrics and Qualimetrics. Vol 20 B, (1998), Elsevier.
Articles, a selection:
- Lewi P.J. (1976). "Spectral mapping, a technique for classifying biological activity profiles of chemical compounds. Arzneim. Forsch". in: Drug Res. 26, 1295-1300.
- Lewi P.J. (1981). "Multidimensional analysis of pharmacological data". In: Rev Pure Appl Pharmacol Sci. 1981 Jul-Sep;2(3):229-90.
- Lewi P.J. (1987). "The use of multivariate statistics in industrial pharmacology". In: Pharmacol Ther [B]. 1978;3(4):481-537.
- Lewi P.J. (1989). "Spectral Map Analysis. Factorial analysis of contrasts, especially from log ratios." In: Chemometr. Intell. Lab. Syst., 5 (2), 105-116, 1989.
- Lewi P.J, Mullie A, Quets A. (1989). "Relevance and significance of pre-CPR conditions in cardio-pulmonary-cerebral resuscitation. A graphic analysis by means of Spectramap". The Cerebral Resuscitation Study Group, Resuscitation. 1989;17 Suppl:S35-44; discussion S199-206.
- Lewi P.J. (1990). K. Andries, B. Dewindt, J. Snoeks, L. Wouters, H. Moereels, P.J. Lewi, "Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity". In: J Virol, 64 (3), 1117–1123, 1990.
- Lewi P.J. (2005). "Spectral mapping, a personal and historical account of an adventure in multivariate data analysis". In: Chemometr. Intell. Lab. Syst., 77, 215-223, 2005.
- 2006. "Speaking of Graphics".