PPADS
Encyclopedia
PPADS is a selective purinergic P2X
antagonist
. It is able to block contractions of rabbit vas deferens induced by ATP
or α,β,methylene-ATP. It appears to be relatively selection for P2X receptors, having no appreciable activity at α1 adrenergic
, muscarinic M2
and M3
, histamine H1, and adenosine A1 receptors.
P2X Receptor
P2X receptors are a family of cation-permeable ligand gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate . They belong to a larger family of receptors known as the purinergic receptors...
antagonist
Antagonist
An antagonist is a character, group of characters, or institution, that represents the opposition against which the protagonist must contend...
. It is able to block contractions of rabbit vas deferens induced by ATP
Adenosine triphosphate
Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
or α,β,methylene-ATP. It appears to be relatively selection for P2X receptors, having no appreciable activity at α1 adrenergic
Alpha-1 adrenergic receptor
The alpha-1 adrenergic receptor is a G protein-coupled receptor associated with the Gq heterotrimeric G-protein. It consists of three highly homologous subtypes, including α1A-, α1B-, and α1D-adrenergic...
, muscarinic M2
Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor.-Heart:...
and M3
Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor M3, also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor. It is encoded by the human gene CHRM3....
, histamine H1, and adenosine A1 receptors.