Otto Busse
Encyclopedia
Otto Emil Franz Ulrich Busse (December 6, 1867 – February 3, 1922) was a German pathologist. Busse was born in Belgard, Pomerania
, Prussia
(today Białogard, Poland) and studied medicine at the University of Greifswald, and subsequently became an assistant to Paul Grawitz
(1850–1932), (his future father-in-law) at Greifswald
. Afterwards he moved to Posen (today Poznan
, Poland), where in 1904 he became a professor of pathology. From 1911 until 1922 he was professor of pathological anatomy at the University of Zurich
, where he died.
In 1894 Busse was the first to describe a yeast-like fungus
known as Cryptococcus neoformans
, which was discovered in a patient with chronic periostitis
of the tibia
. At the time he called the fungus Saccharomyces hominis. Infection caused by the fungus is called cryptococcosis
, or sometimes Busse-Buschke disease, named in conjunction with dermatologist Abraham Buschke
(1868–1943).
Pomerania
Pomerania is a historical region on the south shore of the Baltic Sea. Divided between Germany and Poland, it stretches roughly from the Recknitz River near Stralsund in the West, via the Oder River delta near Szczecin, to the mouth of the Vistula River near Gdańsk in the East...
, Prussia
Prussia
Prussia was a German kingdom and historic state originating out of the Duchy of Prussia and the Margraviate of Brandenburg. For centuries, the House of Hohenzollern ruled Prussia, successfully expanding its size by way of an unusually well-organized and effective army. Prussia shaped the history...
(today Białogard, Poland) and studied medicine at the University of Greifswald, and subsequently became an assistant to Paul Grawitz
Paul Grawitz
Paul Albert Grawitz was a German pathologist. While he studied medicine at the University of Berlin, he was an assistant to pathologist Rudolf Ludwig Karl Virchow . After graduation he continued as assistant to Virchow until 1886...
(1850–1932), (his future father-in-law) at Greifswald
Greifswald
Greifswald , officially, the University and Hanseatic City of Greifswald is a town in northeastern Germany. It is situated in the state of Mecklenburg-Vorpommern, at an equal distance of about from Germany's two largest cities, Berlin and Hamburg. The town borders the Baltic Sea, and is crossed...
. Afterwards he moved to Posen (today Poznan
Poznan
Poznań is a city on the Warta river in west-central Poland, with a population of 556,022 in June 2009. It is among the oldest cities in Poland, and was one of the most important centres in the early Polish state, whose first rulers were buried at Poznań's cathedral. It is sometimes claimed to be...
, Poland), where in 1904 he became a professor of pathology. From 1911 until 1922 he was professor of pathological anatomy at the University of Zurich
University of Zurich
The University of Zurich , located in the city of Zurich, is the largest university in Switzerland, with over 25,000 students. It was founded in 1833 from the existing colleges of theology, law, medicine and a new faculty of philosophy....
, where he died.
In 1894 Busse was the first to describe a yeast-like fungus
Fungus
A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds , as well as the more familiar mushrooms. These organisms are classified as a kingdom, Fungi, which is separate from plants, animals, and bacteria...
known as Cryptococcus neoformans
Cryptococcus neoformans
Cryptococcus neoformans is an encapsulated yeast that can live in both plants and animals. Its teleomorph is Filobasidiella neoformans, a filamentous fungus belonging to the class Tremellomycetes. It is often found in pigeon excrement....
, which was discovered in a patient with chronic periostitis
Periostitis
Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the periosteum, a layer of connective tissue that surrounds bone...
of the tibia
Tibia
The tibia , shinbone, or shankbone is the larger and stronger of the two bones in the leg below the knee in vertebrates , and connects the knee with the ankle bones....
. At the time he called the fungus Saccharomyces hominis. Infection caused by the fungus is called cryptococcosis
Cryptococcosis
Cryptococcosis, or cryptococcal disease, is a potentially fatal fungal disease. It is caused by one of two species; Cryptococcus neoformans and Cryptococcus gattii. These were all previously thought to be subspecies of C...
, or sometimes Busse-Buschke disease, named in conjunction with dermatologist Abraham Buschke
Abraham Buschke
Abraham Buschke was a Jewish German dermatologist who was a native of Nakel in the Province of Posen. In 1891 he received his doctorate in Berlin, and afterwards was a surgical assistant in Greifswald. Later he worked at dermatological clinics in Breslau under Albert Neisser and in Berlin with...
(1868–1943).