Ohio Brush Creek is a 59.9 miles (96.4 km) tributary

Tributary

A tributary or affluent is a stream or river that flows into a main stem river or a lake. A tributary does not flow directly into a sea or ocean...

 of the Ohio River

Ohio River

The Ohio River is the largest tributary, by volume, of the Mississippi River. At the confluence, the Ohio is even bigger than the Mississippi and, thus, is hydrologically the main stream of the whole river system, including the Allegheny River further upstream...

 in southern Ohio

Ohio

Ohio is a Midwestern state in the United States. The 34th largest state by area in the U.S.,it is the 7th‑most populous with over 11.5 million residents, containing several major American cities and seven metropolitan areas with populations of 500,000 or more.The state's capital is Columbus...

 in the United States

United States

The United States of America is a federal constitutional republic comprising fifty states and a federal district...

. Via the Ohio River, it is part of the watershed

Drainage basin

A drainage basin is an extent or an area of land where surface water from rain and melting snow or ice converges to a single point, usually the exit of the basin, where the waters join another waterbody, such as a river, lake, reservoir, estuary, wetland, sea, or ocean...

 of the Mississippi River

Mississippi River

The Mississippi River is the largest river system in North America. Flowing entirely in the United States, this river rises in western Minnesota and meanders slowly southwards for to the Mississippi River Delta at the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains...

, draining an area of 435 square miles (1,126.6 km²). According to the Geographic Names Information System

Geographic Names Information System

The Geographic Names Information System is a database that contains name and locative information about more than two million physical and cultural features located throughout the United States of America and its territories. It is a type of gazetteer...

, it has also been known historically as "Brush Creek," "Elk Creek," and "Little Scioto River

Little Scioto River

Little Scioto River may refer to any of several streams in the state of Ohio in the United States:*Little Scioto River, a tributary of the Ohio River.*Little Scioto River, a tributary of the Scioto River....

"

Ohio Brush Creek rises in southeastern Highland County

Highland County, Ohio

As of the census of 2000, there were 40,875 people, 15,587 households, and 11,394 families residing in the county. The population density was 74 people per square mile . There were 17,583 housing units at an average density of 32 per square mile...

, and flows generally southwardly into Adams County

Adams County, Ohio

As of the census of 2000, there were 27,330 people, 10,501 households, and 7,613 families residing in the county. The population density was 47 people per square mile . There were 11,822 housing units at an average density of 20 per square mile...

, past the Serpent Mound

Serpent Mound

The Great Serpent Mound is a -long, three-foot-high prehistoric effigy mound located on a plateau of the Serpent Mound crater along Ohio Brush Creek in Adams County, Ohio. Maintained within a park by the Ohio Historical Society, it has been designated a National Historic Landmark by the United...

, to its confluence at the Ohio River, about 4 miles (6 km) west of Rome

Rome, Ohio

Rome is a village in Adams County, Ohio, United States, along the Ohio River. The population was 117 at the 2000 census.-Geography:Rome is located at ....

.