The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the NCOR1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...

 interacting domains. In addition, NCOR1 appears to recruit histone deacetylase

Histone deacetylase

Histone deacetylases are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone...

s to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

Loss of function of this protein significantly increases the strength and power of mouse muscles.

Interactions

Nuclear receptor co-repressor 1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with HDAC9

HDAC9

Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene.-Interactions:HDAC9 has been shown to interact with SIN3A, Nuclear receptor co-repressor 1, CBX5, HDAC3, Myocyte-specific enhancer factor 2A and SUV39H1....

, CHD1

CHD1

Chromodomain-helicase-DNA-binding protein 1 is an enzyme that in humans is encoded by the CHD1 gene.-Interactions:CHD1 has been shown to interact with Nuclear receptor co-repressor 1.-Further reading:...

, HDAC7A

HDAC7A

Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.-Interactions:HDAC7A has been shown to interact with Endothelin receptor type A, HDAC3, HTATIP, BCL6, Nuclear receptor co-repressor 1 and IKZF1.-Further reading:...

, MAP3K7IP2

MAP3K7IP2

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK...

, Glucocorticoid receptor

Glucocorticoid receptor

The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....

, MECP2

MECP2

MECP2 is a gene that provides instructions for making its protein product, MECP2, also referred to as MeCP2. MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels...

, Peroxisome proliferator-activated receptor alpha

Peroxisome proliferator-activated receptor alpha

Peroxisome proliferator-activated receptor alpha , also known as NR1C1 , is a nuclear receptor protein that in humans is encoded by the PPARA gene.- Function :...

, HEY2

HEY2

Hairy/enhancer-of-split related with YRPW motif protein 2 also known as cardiovascular helix-loop-helix factor 1 is a protein that in humans is encoded by the HEY2 gene.- Function :...

, Histone deacetylase 5

Histone deacetylase 5

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.-Interactions:Histone deacetylase 5 has been shown to interact with Zinc finger and BTB domain-containing protein 16, BCL6, CBX5, YWHAQ, Myocyte-specific enhancer factor 2A, Nuclear receptor co-repressor 1, IKZF1,...

, TBL1XR1

TBL1XR1

F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the TBL1XR1 gene.-Interactions:TBL1XR1 has been shown to interact with Nuclear receptor co-repressor 1.-Further reading:...

, TBL1X

TBL1X

Transducin -like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.- Function :The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to...

, HDAC3

HDAC3

Histone deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene.-Interactions:HDAC3 has been shown to interact with HDAC9, HDAC7A, Retinoblastoma protein, RBBP4, Testicular receptor 2, MAP3K7IP2, Peroxisome proliferator-activated receptor delta, GTF2I, Histone deacetylase 5, RELA,...

, ZBTB33

ZBTB33

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.-Interactions:ZBTB33 has been shown to interact with HDAC3, Nuclear receptor co-repressor 1 and CTNND1....

, Retinoic acid receptor alpha

Retinoic acid receptor alpha

Retinoic acid receptor alpha , also known as NR1B1 is a nuclear receptor that in humans is encoded by the RARA gene.- Function :...

, SAP30

SAP30

Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene.- Function :Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes...

, Androgen receptor

Androgen receptor

The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...

, Retinoic acid receptor gamma

Retinoic acid receptor gamma

Retinoic acid receptor gamma , also known as NR1B3 is a nuclear receptor encoded by the RARG gene.- Interactions :...

, RUNX1T1

RUNX1T1

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.-Interactions:RUNX1T1 has been shown to interact with CBFA2T2, Zinc finger and BTB domain-containing protein 16, Nuclear receptor co-repressor 1, Nuclear receptor co-repressor 2, CBFA2T3, GFI1, Calcitriol receptor and...

, HDAC4

HDAC4

Histone deacetylase 4, also known as HDAC4, is a protein which in humans is encoded by the HDAC4 gene.- Function :Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects...

, GPS2

GPS2 (gene)

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.-Interactions:GPS2 has been shown to interact with Cyclin A1, TBL1X, Nuclear receptor co-repressor 1, P53, EP300, HDAC3 and C21orf7.-Further reading:...

, Calcitriol receptor

Calcitriol receptor

The calcitriol receptor, also known as the vitamin D receptor and also known as NR1I1 , is a member of the nuclear receptor family of transcription factors...

 and Promyelocytic leukemia protein

Promyelocytic leukemia protein

Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing...

.