Norsalsolinol
Encyclopedia
Norsalsolinol is a chemical compound that is produced naturally in the body through metabolism
of dopamine
. It has been shown to be a selective dopaminergic neurotoxin
, and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease
and the brain damage associated with alcoholism
, although evidence for a causal relationship is unclear.
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
of dopamine
Dopamine
Dopamine is a catecholamine neurotransmitter present in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this substituted phenethylamine functions as a neurotransmitter, activating the five known types of dopamine receptors—D1, D2, D3, D4, and D5—and their...
. It has been shown to be a selective dopaminergic neurotoxin
Neurotoxin
A neurotoxin is a toxin that acts specifically on nerve cells , usually by interacting with membrane proteins such as ion channels. Some sources are more general, and define the effect of neurotoxins as occurring at nerve tissue...
, and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease
Parkinson's disease
Parkinson's disease is a degenerative disorder of the central nervous system...
and the brain damage associated with alcoholism
Alcoholism
Alcoholism is a broad term for problems with alcohol, and is generally used to mean compulsive and uncontrolled consumption of alcoholic beverages, usually to the detriment of the drinker's health, personal relationships, and social standing...
, although evidence for a causal relationship is unclear.