Nkx2-2as
Encyclopedia
Nkx2-2as is a long non-coding RNA. It is located in the cytoplasm
of the cell
. Nkx2-2as is involved in Neural development
. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox
gene Nkx2-2
and enhances induction of the differentiation
of oligodendrocytes. Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
of the cell
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos....
. Nkx2-2as is involved in Neural development
Neural development
Neural development comprises the processes that generate, shape, and reshape the nervous system, from the earliest stages of embryogenesis to the final years of life. The study of neural development aims to describe the cellular basis of brain development and to address the underlying mechanisms...
. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox
Homeobox
A homeobox is a DNA sequence found within genes that are involved in the regulation of patterns of anatomical development in animals, fungi and plants.- Discovery :...
gene Nkx2-2
NKX2-2
Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated...
and enhances induction of the differentiation
Cellular differentiation
In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation occurs numerous times during the development of a multicellular organism as the organism changes from a simple zygote to a complex system of...
of oligodendrocytes. Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.