Niementowski quinoline synthesis
Encyclopedia
The Niementowski quinoline synthesis is the chemical reaction
of anthranilic acid
s and ketone
s (or aldehyde
s) to form γ-hydroxyquinoline derivatives.
Several reviews have been published.
Chemical reaction
A chemical reaction is a process that leads to the transformation of one set of chemical substances to another. Chemical reactions can be either spontaneous, requiring no input of energy, or non-spontaneous, typically following the input of some type of energy, such as heat, light or electricity...
of anthranilic acid
Anthranilic acid
Anthranilic acid is the organic compound with the formula C6H4COOH. This amino acid is a white solid when pure, although commercial samples may appear yellow. The molecule consists of a benzene ring with two adjacent functional groups, a carboxylic acid and an amine...
s and ketone
Ketone
In organic chemistry, a ketone is an organic compound with the structure RCR', where R and R' can be a variety of atoms and groups of atoms. It features a carbonyl group bonded to two other carbon atoms. Many ketones are known and many are of great importance in industry and in biology...
s (or aldehyde
Aldehyde
An aldehyde is an organic compound containing a formyl group. This functional group, with the structure R-CHO, consists of a carbonyl center bonded to hydrogen and an R group....
s) to form γ-hydroxyquinoline derivatives.
See also
- Camps quinoline synthesisCamps quinoline synthesisThe Camps quinoline synthesis is a chemical reaction whereby an o-acylaminoacetophenone is transformed into two different hydroxyquinolines using hydroxide ion....
- Friedländer synthesisFriedländer synthesisThe Friedländer synthesis is the chemical reaction of 2-aminobenzaldehydes with ketones to form quinoline derivatives. It is named after German chemist Paul Friedländer ....
- Niementowski quinazoline synthesisNiementowski quinazoline synthesisThe Niementowski quinazoline synthesis is the chemical reaction of anthranilic acids with amides to form 4-oxo-3,4-dihydroquinazolines.-References:# Stefan Niementowski, v. J. Prakt. Chem. 1895, 51, 564....
- Pfitzinger reactionPfitzinger reactionThe Pfitzinger reaction is the chemical reaction of isatin with base and a carbonyl compound to yield substituted quinoline-4-carboxylic acids.Several reviews have been published.-Reaction mechanism:...