The neuropeptide FF receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptide

Neuropeptide

Neuropeptides are small protein-like molecules used by neurons to communicate with each other. They are neuronal signaling molecules, influence the activity of the brain in specific ways and are thus involved in particular brain functions, like analgesia, reward, food intake, learning and...

s AF and FF. These neuropeptides are thought to be involved in modulation of opioid receptor

Opioid receptor

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin receptors...

 function in the brain and spinal cord, and can either reduce or increase opioid receptor function depending which tissue they are released in, reflecting a complex role for neuropeptide FF in pain responses.

Antagonists

• BIBP-3226
  BIBP-3226
  BIBP-3226 is a drug used in scientific research which acts as a potent and selective antagonist for both the Neuropeptide Y receptor Y1 and also the neuropeptide FF receptor. It was the first non-peptide antagonist developed for the Y1 receptor and has been widely used to help determine its...
  
   (mixed NPFF₁ / NPY₁
  Neuropeptide Y receptor Y1
  Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.-Antagonists:Peptide* BVD-10 * GR-231,118 Non-peptide...
  
  antagonist)
• RF-9

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