BIBP-3226
Encyclopedia
BIBP-3226 is a drug used in scientific research which acts as a potent and selective antagonist
for both the Neuropeptide Y
receptor Y1
and also the neuropeptide FF receptor
. It was the first non-peptide antagonist developed for the Y1 receptor and has been widely used to help determine its functions in the body. Activation of Y1 is thought to be involved in functions such as regulation of appetite and anxiety, and BIBP-3226 has anxiogenic
and anorectic
effects, as well as blocking the Y1-mediated corticotropin releasing hormone release. It has also been used as a lead compound
to develop a number of newer more potent Y1 antagonists.
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
for both the Neuropeptide Y
Neuropeptide Y
Neuropeptide Y is a 36-amino acid peptide neurotransmitter found in the brain and autonomic nervous system."NPY has been associated with a number of physiologic processes in the brain, including the regulation of energy balance, memory and learning, and epilepsy." The main effect is increased food...
receptor Y1
Neuropeptide Y receptor Y1
Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.-Antagonists:Peptide* BVD-10 * GR-231,118 Non-peptide...
and also the neuropeptide FF receptor
Neuropeptide FF receptor
The neuropeptide FF receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides AF and FF...
. It was the first non-peptide antagonist developed for the Y1 receptor and has been widely used to help determine its functions in the body. Activation of Y1 is thought to be involved in functions such as regulation of appetite and anxiety, and BIBP-3226 has anxiogenic
Anxiogenic
An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice. A number of agents are used to provoke anxiety or panic in experimental models...
and anorectic
Anorectic
An anorectic or anorexic , also known as anorexigenic or appetite suppressant, is a dietary supplement and/or drug which reduces appetite, food consumption, and as a result, causes weight loss to occur.-List of anorectics:Numerous pharmaceutical compounds are marketed as appetite suppressants.The...
effects, as well as blocking the Y1-mediated corticotropin releasing hormone release. It has also been used as a lead compound
Lead compound
A lead compound in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters.Lead compounds are often found in...
to develop a number of newer more potent Y1 antagonists.